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Tbio
STOML2
Stomatin-like protein 2, mitochondrial

Protein Summary
Description
Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356493
  • ENSP00000348886
  • ENSG00000165283
  • ENST00000452248
  • ENSP00000395743

Symbol
  • SLP2
  • SLP-2
  • HSPC108
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
interacting protein
0.99
disease perturbation
0.95
kinase perturbation
0.84
histone modification site profile
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.57   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 234   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.57   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (80)
PRKAR1A
Tbio
Family:  Enzyme
Novelty:  0.00311432
p_int:  0.97291273
p_ni:  0.02708727
Score:  0.545
Data Source:  BioPlex,STRINGDB
PHB2
Tbio
Novelty:  0.00458856
Score:  0.934
Data Source:  STRINGDB
YME1L1
Tbio
Family:  Enzyme
Novelty:  0.00180835
Score:  0.926
Data Source:  Reactome,STRINGDB
PHB
Tbio
Novelty:  0.00178383
Score:  0.916
Data Source:  STRINGDB
PARL
Tchem
Family:  Enzyme
Novelty:  0.01317944
Score:  0.915
Data Source:  Reactome,STRINGDB
SMDT1
Tbio
Novelty:  0.02448475
Score:  0.906
Data Source:  STRINGDB
ATP5F1A
Tbio
Family:  Enzyme
Novelty:  0.01052213
Score:  0.887
Data Source:  STRINGDB
MRPL32
Tdark
Novelty:  0.58976136
Score:  0.879
Data Source:  STRINGDB
MRPL40
Tbio
Novelty:  0.09916967
Score:  0.852
Data Source:  STRINGDB
HSPA1L
Tbio
Novelty:  0.01658161
Score:  0.836
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Mitochondrial calcium ion transport (R-HSA-8949215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial calcium ion transport
Reactome
Processing of SMDT1
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Mitochondrial calcium ion transport
Processing of SMDT1
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
2
2
48
platelet count
1
1
1
47.2
mean platelet volume
1
1
1
43.2
mean corpuscular volume
1
1
1
22.6
mean reticulocyte volume
1
1
1
19.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
48
platelet count
1
47.2
mean platelet volume
1
43.2
mean corpuscular volume
1
22.6
mean reticulocyte volume
1
19.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
stomatin like 2
VGNC:8938
465069
Macaque
stomatin like 2
698458
Mouse
MGI:1913842
66592
Rat
RGD:1308285
298203
Horse
stomatin like 2
VGNC:23705
100055756
Species
Name
OMA
EggNOG
Inparanoid
Chimp
stomatin like 2
Macaque
stomatin like 2
Mouse
Rat
Horse
stomatin like 2
Publication Statistics
PubMed Score 19.57
PubMed score by year
PubTator Score 42.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title