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Tbio
STOM
Erythrocyte band 7 integral membrane protein

Protein Summary
Description
Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity. This gene encodes a member of a highly conserved family of integral membrane proteins. The encoded protein localizes to the cell membrane of red blood cells and other cell types, where it may regulate ion channels and transporters. Loss of localization of the encoded protein is associated with hereditary stomatocytosis, a form of hemolytic anemia. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286713
  • ENSP00000286713
  • ENSG00000148175
  • ENST00000347359
  • ENSP00000339607

Symbol
  • BND7
  • EPB72
  • BND7
  • EPB7
  • EPB72
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
interacting protein
0.96
disease perturbation
0.95
kinase perturbation
0.93
small molecule perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.78   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 241   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.78   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (235)
FAF2
Tbio
Novelty:  0.03048598
p_int:  0.996232034
p_ni:  0.003767966
Score:  0.235
Data Source:  BioPlex,STRINGDB
SMPD3
Tchem
Family:  Enzyme
Novelty:  0.01053328
p_int:  0.995103733
p_ni:  0.004896266
p_wrong:  1e-9
Score:  0.2
Data Source:  BioPlex,STRINGDB
SERINC2
Tbio
Novelty:  0.13677995
p_int:  0.970169055
p_ni:  0.029830945
Score:  0.223
Data Source:  BioPlex,STRINGDB
GIMAP2
Tbio
Family:  Enzyme
Novelty:  0.05969307
p_int:  0.925061667
p_ni:  0.074938333
Score:  0.534
Data Source:  BioPlex,STRINGDB
ARHGAP36
Tbio
Family:  Enzyme
Novelty:  0.33342126
p_int:  0.919571297
p_ni:  0.080428695
p_wrong:  9e-9
Score:  0.159
Data Source:  BioPlex,STRINGDB
ERGIC3
Tbio
Novelty:  0.11095443
p_int:  0.820278853
p_ni:  0.179721145
p_wrong:  2e-9
Score:  0.174
Data Source:  BioPlex,STRINGDB
SPRED2
Tbio
Novelty:  0.04447225
p_int:  0.81677865
p_ni:  0.183219407
p_wrong:  0.000001943
Score:  0.188
Data Source:  BioPlex,STRINGDB
SSMEM1
Tdark
Novelty:  1.77966102
p_int:  0.762047609
p_ni:  0.237952391
Score:  0.189
Data Source:  BioPlex,STRINGDB
ASIC2
Tchem
Family:  IC
Novelty:  0.00255005
Score:  0.97
Data Source:  STRINGDB
ASIC3
Tchem
Family:  IC
Novelty:  0.0038099
Score:  0.969
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Ion channel transport
Reactome
Neutrophil degranulation
Reactome
Stimuli-sensing channels
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Ion channel transport
Neutrophil degranulation
Stimuli-sensing channels
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
1
1
46.9
hemoglobin measurement
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
46.9
hemoglobin measurement
1
40.7
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
stomatin
VGNC:13971
464707
Macaque
stomatin
699584
Mouse
MGI:95403
13830
Rat
RGD:1305109
296655
Dog
stomatin
VGNC:46931
612719
Species
Name
OMA
EggNOG
Inparanoid
Chimp
stomatin
Macaque
stomatin
Mouse
Rat
Dog
stomatin
Publication Statistics
PubMed Score 209.78
PubMed score by year
PubTator Score 37.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title