You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
STMN1
Stathmin

Protein Summary
Description
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357865
  • ENSP00000350531
  • ENSG00000117632
  • ENST00000374291
  • ENSP00000363409
  • ENST00000399728
  • ENSP00000382633
  • ENST00000426559
  • ENSP00000410452
  • ENST00000455785
  • ENSP00000387858

Symbol
  • C1orf215
  • LAP18
  • OP18
  • Lag
  • SMN
  • OP18
  • PP17
  • PP19
  • PR22
  • LAP18
  • C1orf215
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
1
kinase perturbation
1
PubMedID
0.99
hub protein
0.98
ligand (protein) perturbation
0.96


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1090.48   (req: < 5)
Gene RIFs: 175   (req: <= 3)
Antibodies: 1329   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1090.48   (req: >= 5)
Gene RIFs: 175   (req: > 3)
Antibodies: 1329   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0