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Tchem
STK38L
Serine/threonine-protein kinase 38-like

Protein Summary
Description
Involved in the regulation of structural processes in differentiating and mature neuronal cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389032
  • ENSP00000373684
  • ENSG00000211455

Symbol
  • KIAA0965
  • NDR2
  • NDR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
protein domain
0.92
transcription factor binding site profile
0.88
kinase perturbation
0.84
transcription factor perturbation
0.84


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.69   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 223   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.69   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (70)
MOB1B
Tbio
Family:  Enzyme
Novelty:  0.0718959
p_int:  1
Score:  0.969
Data Source:  BioPlex,STRINGDB
MOB2
Tbio
Family:  Enzyme
Novelty:  0.02691673
p_int:  0.999999995
p_ni:  4e-9
p_wrong:  2e-9
Score:  0.942
Data Source:  BioPlex,STRINGDB
MOB1A
Tbio
Family:  Enzyme
Novelty:  0.01430129
p_int:  0.999999894
p_ni:  1.06e-7
Score:  0.972
Data Source:  BioPlex,STRINGDB
PRPH
Tbio
Novelty:  0.25890973
p_int:  0.999978434
p_ni:  0.000021542
p_wrong:  2.4e-8
Score:  0.429
Data Source:  BioPlex,STRINGDB
LAMTOR5
Tbio
Novelty:  0.003692
p_int:  0.999509943
p_ni:  0.000490055
p_wrong:  2e-9
Data Source:  BioPlex
SLC25A25
Tbio
Family:  Transporter
Novelty:  0.05562006
p_int:  0.982126707
p_ni:  0.017873292
p_wrong:  1e-9
Score:  0.207
Data Source:  BioPlex,STRINGDB
NDRG3
Tbio
Novelty:  0.05968882
Score:  0.908
Data Source:  STRINGDB
NDRG2
Tbio
Novelty:  0.01061428
Score:  0.907
Data Source:  STRINGDB
NDRG1
Tbio
Novelty:  0.00352631
Score:  0.907
Data Source:  STRINGDB
S100B
Tchem
Novelty:  0.00031007
Score:  0.877
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Overview of leukocyte-intrinsic Hippo pathway functions
WikiPathways
Hippo-Yap signaling pathway
Name
Explore in Pharos
Explore in Source
Overview of leukocyte-intrinsic Hippo pathway functions
Hippo-Yap signaling pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
1
2
68.3
BMI-adjusted waist-hip ratio
2
3
3
57.1
1
1
0
2.1
54.4
waist-hip ratio
1
2
2
45.6
mathematical ability
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
68.3
BMI-adjusted waist-hip ratio
3
57.1
0
2.1
54.4
waist-hip ratio
2
45.6
mathematical ability
1
29
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase 38 like
VGNC:8584
738561
Macaque
serine/threonine kinase 38 like
711047
Mouse
MGI:1922250
232533
Rat
RGD:1564793
691337
Dog
serine/threonine kinase 38 like
VGNC:46920
477663
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase 38 like
Macaque
serine/threonine kinase 38 like
Mouse
Rat
Dog
serine/threonine kinase 38 like
Publication Statistics
PubMed Score 21.69
PubMed score by year
PubTator Score 17.49
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title