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Tchem
STK35
Serine/threonine-protein kinase 35

Protein Summary
Description
The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381482
  • ENSP00000370891
  • ENSG00000125834

Symbol
  • CLIK1
  • PDIK1
  • STK35L1
  • CLIK1
  • STK35L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
transcription factor binding site profile
0.88
microRNA
0.83
PubMedID
0.64
tissue sample
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.5   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 170   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.5   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (56)
CTDSPL2
Tbio
Family:  Enzyme
Novelty:  0.23254058
p_int:  0.999999996
p_ni:  3e-9
p_wrong:  1e-9
Score:  0.298
Data Source:  BioPlex,STRINGDB
HSP90AB3P
Tdark
p_int:  0.99999946
p_ni:  5.4e-7
Data Source:  BioPlex
HSP90AA5P
Tdark
p_int:  0.99999883
p_ni:  0.00000117
Data Source:  BioPlex
HSP90AB4P
Tdark
p_int:  0.999994841
p_ni:  0.000005157
p_wrong:  2e-9
Data Source:  BioPlex
C1orf174
Tdark
Novelty:  4.20172485
p_int:  0.999992263
p_ni:  0.000007737
Score:  0.282
Data Source:  BioPlex,STRINGDB
CDC37L1
Tbio
Novelty:  0.11043692
p_int:  0.99999015
p_ni:  3.31e-7
p_wrong:  0.000009519
Score:  0.285
Data Source:  BioPlex,STRINGDB
HSP90AA4P
Tdark
p_int:  0.999989068
p_ni:  0.000010668
p_wrong:  2.64e-7
Data Source:  BioPlex
UBP1
Tbio
Family:  TF
Novelty:  0.01140885
p_int:  0.999593298
p_ni:  0.0004067
p_wrong:  2e-9
Score:  0.747
Data Source:  BioPlex,STRINGDB
CDC37
Tbio
Novelty:  0.03730196
p_int:  0.997028957
p_ni:  0.002971043
Score:  0.18
Data Source:  BioPlex,STRINGDB
HSP90AA1
Tchem
Novelty:  0.00016774
p_int:  0.991105975
p_ni:  0.008894025
Score:  0.165
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
4
3
1.2
98.8
keratinocyte carcinoma
1
2
0
1.1
86.2
central corneal thickness
1
2
0
1.7
43.1
body height
1
1
1
41.8
corneal resistance factor
1
1
1
41.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.2
98.8
keratinocyte carcinoma
0
1.1
86.2
central corneal thickness
0
1.7
43.1
body height
1
41.8
corneal resistance factor
1
41.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase 35
VGNC:14304
458041
Macaque
serine/threonine kinase 35
716423
Mouse
MGI:1914583
67333
Rat
RGD:1310247
311419
Dog
serine/threonine kinase 35
VGNC:46917
609432
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase 35
Macaque
serine/threonine kinase 35
Mouse
Rat
Dog
serine/threonine kinase 35
Publication Statistics
PubMed Score 12.50
PubMed score by year
PubTator Score 5.48
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title