Tchem STK33 Serine/threonine-protein kinase 33

Protein Summary

Description

Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Not essential for the survival of KRAS-dependent AML cell lines.

Uniprot Accession IDs

• Q9BYT3
• Q658S6
• Q8NEF5

Gene Name

• STK33

Ensembl ID

• ENST00000315204
• ENSP00000320754
• ENSG00000130413
• ENST00000396672
• ENSP00000379905
• ENST00000447869
• ENSP00000416750

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.9
protein domain	0.85
histone modification site profile	0.78
interacting protein	0.62
microRNA	0.62

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Camk-unique Family / Serine/threonine-protein Kinase 33

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.78   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 389   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.78   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1