You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
STK17B
Serine/threonine-protein kinase 17B

Protein Summary
Description
Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263955
  • ENSP00000263955
  • ENSG00000081320
  • ENST00000409228
  • ENSP00000386853

Symbol
  • DRAK2
  • DRAK2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
molecular function
0.9
transcription factor binding site profile
0.84
PubMedID
0.81
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.85   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 403   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.85   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 403   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (38)
LAMP1
Tbio
Novelty:  0.00067563
p_int:  0.999989527
p_ni:  0.000006822
p_wrong:  0.000003651
Score:  0.175
Data Source:  BioPlex,STRINGDB
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.999838172
p_ni:  0.000159967
p_wrong:  0.000001861
Data Source:  BioPlex
KCNIP2
Tbio
Family:  IC
Novelty:  0.01123517
p_int:  0.998804033
p_ni:  0.000988614
p_wrong:  0.000207353
Score:  0.344
Data Source:  BioPlex,STRINGDB
P2RX5
Tchem
Family:  IC
Novelty:  0.01591178
p_int:  0.994173003
p_ni:  0.005622384
p_wrong:  0.000204613
Data Source:  BioPlex
SLC2A9
Tbio
Family:  Transporter
Novelty:  0.00683926
p_int:  0.976688407
p_ni:  0.022939643
p_wrong:  0.00037195
Data Source:  BioPlex
TPM2
Tbio
Novelty:  0.00406572
p_int:  0.936804197
p_ni:  0.04641244
p_wrong:  0.016783363
Score:  0.245
Data Source:  BioPlex,STRINGDB
CHRM4
Tclin
Family:  GPCR
Novelty:  0.00759817
p_int:  0.90949346
p_ni:  0.064037058
p_wrong:  0.026469482
Data Source:  BioPlex
TMEM30A
Tbio
Novelty:  0.05115559
p_int:  0.858036291
p_ni:  0.036603283
p_wrong:  0.105360425
Score:  0.161
Data Source:  BioPlex,STRINGDB
LPAR6
Tchem
Family:  GPCR
Novelty:  0.01801122
p_int:  0.855533326
p_ni:  0.076296063
p_wrong:  0.068170611
Score:  0.159
Data Source:  BioPlex,STRINGDB
CHSY3
Tdark
Family:  Enzyme
Novelty:  0.17103933
p_int:  0.820012578
p_ni:  0.17679108
p_wrong:  0.003196342
Score:  0.165
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
64.4
mean corpuscular volume
1
1
1
61
eosinophil percentage of leukocytes
1
1
1
53.7
eosinophil count
2
1
2
46.5
red blood cell distribution width
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
64.4
mean corpuscular volume
1
61
eosinophil percentage of leukocytes
1
53.7
eosinophil count
2
46.5
red blood cell distribution width
1
38.8
Find similar targets by:
IDG Resources
Chemical Tool
2-((6-(3-fluoro-4-methoxyphenyl)thieno[3,2-d]pyrimidin-4-yl)thio)acetic acid
image for 2-((6-(3-fluoro-4-methoxyphenyl)thieno[3,2-d]pyrimidin-4-yl)thio)acetic acid
Details:
  • ChEBI:  143111
  • Provider:  UNC-CH
  • Activity:  670 nM
  • Selectivity:  0.002
Chemical Tool
2-((6-(benzo[b]thiophen-2-yl)thieno[3,2-d]pyrimidin-4-yl)thio)acetic acid
image for 2-((6-(benzo[b]thiophen-2-yl)thieno[3,2-d]pyrimidin-4-yl)thio)acetic acid
Details:
  • ChEBI:  156442
  • Provider:  UNC-CH
  • Activity:  670 nM
  • Selectivity:  0.002
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase 17b
VGNC:2872
459843
Mouse
MGI:2138162
98267
Rat
RGD:620457
170904
Dog
serine/threonine kinase 17b
VGNC:46908
488453
Horse
serine/threonine kinase 17b
VGNC:23684
100054971
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase 17b
Mouse
Rat
Dog
serine/threonine kinase 17b
Horse
serine/threonine kinase 17b
Publication Statistics
PubMed Score 35.85
PubMed score by year
PubTator Score 12.86
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title