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Tbio
STIM2
Stromal interaction molecule 2

Protein Summary
Description
Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene init ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000639640
  • ENSP00000492400
  • ENSG00000109689

Symbol
  • KIAA1482
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
transcription factor binding site profile
0.91
microRNA
0.72
transcription factor
0.68
cell line
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 286.4   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 250   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 286.4   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
STIM1
Tbio
Novelty:  0.00116516
p_int:  0.999999883
p_ni:  1.18e-7
Score:  0.883
Data Source:  BioPlex,STRINGDB
BRINP3
Tbio
Novelty:  0.07870037
p_int:  0.999998394
p_ni:  0.000001606
Data Source:  BioPlex
PRKAA1
Tclin
Family:  Kinase
Novelty:  0.01205826
p_int:  0.999941769
p_ni:  0.000058231
Score:  0.828
Data Source:  BioPlex,STRINGDB
PRKAG2
Tchem
Family:  Enzyme
Novelty:  0.00741608
p_int:  0.999393335
p_ni:  0.000564567
p_wrong:  0.000042098
Score:  0.825
Data Source:  BioPlex,STRINGDB
PRKAG1
Tchem
Family:  Kinase
Novelty:  0.07735301
p_int:  0.998806739
p_ni:  0.001193236
p_wrong:  2.5e-8
Score:  0.817
Data Source:  BioPlex,STRINGDB
PRKAB1
Tchem
Family:  Kinase
Novelty:  0.01610606
p_int:  0.998798
p_ni:  0.001201904
p_wrong:  9.6e-8
Score:  0.817
Data Source:  BioPlex,STRINGDB
PRKAB2
Tchem
Family:  Enzyme
Novelty:  0.02815065
p_int:  0.998616428
p_ni:  0.001383544
p_wrong:  2.8e-8
Score:  0.815
Data Source:  BioPlex,STRINGDB
PRKAA2
Tchem
Family:  Kinase
Novelty:  0.01795523
p_int:  0.99574961
p_ni:  0.00425039
Score:  0.874
Data Source:  BioPlex,STRINGDB
MSRB3
Tbio
Family:  Enzyme
Novelty:  0.02843512
p_int:  0.882932693
p_ni:  0.117067299
p_wrong:  8e-9
Data Source:  BioPlex
SUMF1
Tbio
Family:  Enzyme
Novelty:  0.00954537
p_int:  0.857679484
p_ni:  0.019502784
p_wrong:  0.122817733
Score:  0.213
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
2
2
2
79.1
Varicose veins
1
1
1
47.4
Agents acting on the renin-angiotensin system use measurement
2
2
2
33.3
diastolic blood pressure
2
1
2
32.1
mean arterial pressure
1
1
1
5.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
2
79.1
Varicose veins
1
47.4
Agents acting on the renin-angiotensin system use measurement
2
33.3
diastolic blood pressure
2
32.1
mean arterial pressure
1
5.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
stromal interaction molecule 2
VGNC:689
461155
Macaque
stromal interaction molecule 2
694980
Mouse
MGI:2151156
116873
Rat
RGD:1304641
117087
Dog
stromal interaction molecule 2
VGNC:46902
479120
Species
Name
OMA
EggNOG
Inparanoid
Chimp
stromal interaction molecule 2
Macaque
stromal interaction molecule 2
Mouse
Rat
Dog
stromal interaction molecule 2
Publication Statistics
PubMed Score 286.40
PubMed score by year
PubTator Score 71.39
PubTator score by year
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Related Publications
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PMID
Year
Title