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Tbio
STC2
Stanniocalcin-2

Protein Summary
Description
Has an anti-hypocalcemic action on calcium and phosphate homeostasis. This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265087
  • ENSP00000265087
  • ENSG00000113739

Symbol
  • STC-2
  • STCRP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.99
small molecule perturbation
0.96
gene perturbation
0.95
transcription factor binding site profile
0.91
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.55   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 379   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.55   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 379   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (147)
LY86
Tbio
Novelty:  0.00314575
p_int:  0.902738453
p_ni:  0.097260796
p_wrong:  7.52e-7
Data Source:  BioPlex
CCNJL
Tdark
Novelty:  2.86306774
p_int:  0.873216427
p_ni:  0.126783573
Score:  0.453
Data Source:  BioPlex,STRINGDB
CRP
Tbio
Novelty:  0.00001517
p_int:  0.867209221
p_ni:  0.132786082
p_wrong:  0.000004698
Score:  0.187
Data Source:  BioPlex,STRINGDB
MMP19
Tbio
Family:  Enzyme
Novelty:  0.01407961
p_int:  0.754290361
p_ni:  0.245706624
p_wrong:  0.000003016
Data Source:  BioPlex
FAM20C
Tbio
Family:  Enzyme
Novelty:  0.00318966
Score:  0.945
Data Source:  STRINGDB
IGFBP4
Tchem
Novelty:  0.00286837
Score:  0.943
Data Source:  STRINGDB
IGFBP3
Tchem
Novelty:  0.0003776
Score:  0.932
Data Source:  STRINGDB
IGFBP5
Tchem
Novelty:  0.0025185
Score:  0.931
Data Source:  STRINGDB
IGFBP1
Tchem
Novelty:  0.0006975
Score:  0.925
Data Source:  STRINGDB
PENK
Tbio
Novelty:  0.00074167
Score:  0.921
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
5
3
7
95.5
2
2
0
1.1
89.1
QT interval
2
2
2
82
TPE interval measurement
1
2
2
66.7
1
1
0
1.5
60.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
7
95.5
0
1.1
89.1
QT interval
2
82
TPE interval measurement
2
66.7
0
1.5
60.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
stanniocalcin 2
VGNC:4184
462274
Macaque
stanniocalcin 2
703900
Mouse
MGI:1316731
20856
Rat
RGD:621777
63878
Dog
stanniocalcin 2
VGNC:46896
489112
Species
Name
OMA
EggNOG
Inparanoid
Chimp
stanniocalcin 2
Macaque
stanniocalcin 2
Mouse
Rat
Dog
stanniocalcin 2
Publication Statistics
PubMed Score 161.55
PubMed score by year
PubTator Score 65.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title