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Tbio
STAU2
Double-stranded RNA-binding protein Staufen homolog 2

Protein Summary
Description
RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript varian ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355780
  • ENSP00000348026
  • ENSG00000040341
  • ENST00000517542
  • ENSP00000431111
  • ENST00000521210
  • ENSP00000429173
  • ENST00000521451
  • ENSP00000428476
  • ENST00000522509
  • ENSP00000427977
  • ENST00000522695
  • ENSP00000428456
  • ENST00000523558
  • ENSP00000428741
  • ENST00000524104
  • ENSP00000430611
  • ENST00000524300
  • ENSP00000428756

Symbol
  • 39K2
  • 39K3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
disease perturbation
0.79
transcription factor
0.76
transcription factor binding site profile
0.76
transcription factor perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.18   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.18   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.995859784
p_ni:  0.004140216
Score:  0.281
Data Source:  BioPlex,STRINGDB
STRBP
Tbio
Novelty:  0.00919158
p_int:  0.990038294
p_ni:  0.009961706
Score:  0.653
Data Source:  BioPlex,STRINGDB
STAU1
Tbio
Novelty:  0.00565778
p_int:  0.980341123
p_ni:  0.019658877
Score:  0.679
Data Source:  BioPlex,STRINGDB
NOP53
Tbio
Novelty:  0.00353077
p_int:  0.97783966
p_ni:  0.02216034
Data Source:  BioPlex
WDR46
Tbio
Novelty:  0.19307408
p_int:  0.967764784
p_ni:  0.032235216
Data Source:  BioPlex
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.963025481
p_ni:  0.036974519
Score:  0.529
Data Source:  BioPlex,STRINGDB
ILF2
Tbio
Novelty:  0.01598188
p_int:  0.94152607
p_ni:  0.05847393
Score:  0.246
Data Source:  BioPlex,STRINGDB
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.940592848
p_ni:  0.059407152
Score:  0.219
Data Source:  BioPlex,STRINGDB
PPAN
Tbio
Novelty:  0.01063709
p_int:  0.919287847
p_ni:  0.080712153
Data Source:  BioPlex
PAIP1
Tbio
Novelty:  0.05922084
p_int:  0.907094837
p_ni:  0.092905163
Score:  0.518
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
1
1
1
44.2
monocyte count
1
1
1
42.3
waist circumference
1
1
1
33.1
balding measurement
1
1
1
31.4
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
1
44.2
monocyte count
1
42.3
waist circumference
1
33.1
balding measurement
1
31.4
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
staufen double-stranded RNA binding protein 2
696034
Mouse
MGI:1352508
29819
Dog
staufen double-stranded RNA binding protein 2
VGNC:46894
477913
Horse
staufen double-stranded RNA binding protein 2
VGNC:23670
100051157
Pig
staufen double-stranded RNA binding protein 2
100516319
Species
Name
OMA
EggNOG
Inparanoid
Macaque
staufen double-stranded RNA binding protein 2
Mouse
Dog
staufen double-stranded RNA binding protein 2
Horse
staufen double-stranded RNA binding protein 2
Pig
staufen double-stranded RNA binding protein 2
Publication Statistics
PubMed Score 34.18
PubMed score by year
PubTator Score 16.44
PubTator score by year
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Related Publications
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PMID
Year
Title