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Tbio
STAU2
Double-stranded RNA-binding protein Staufen homolog 2

Protein Summary
Description
RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript varian ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355780
  • ENSP00000348026
  • ENSG00000040341
  • ENST00000517542
  • ENSP00000431111
  • ENST00000521210
  • ENSP00000429173
  • ENST00000521451
  • ENSP00000428476
  • ENST00000522509
  • ENSP00000427977
  • ENST00000522695
  • ENSP00000428456
  • ENST00000523558
  • ENSP00000428741
  • ENST00000524104
  • ENSP00000430611
  • ENST00000524300
  • ENSP00000428756

Symbol
  • 39K2
  • 39K3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
disease perturbation
0.79
transcription factor
0.76
transcription factor binding site profile
0.76
transcription factor perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.76   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.76   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0