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Tbio
STAU1
Double-stranded RNA-binding protein Staufen homolog 1

Protein Summary
Description
Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340954
  • ENSP00000345425
  • ENSG00000124214
  • ENST00000347458
  • ENSP00000323443
  • ENST00000360426
  • ENSP00000353604
  • ENST00000371802
  • ENSP00000360867
  • ENST00000371828
  • ENSP00000360893
  • ENST00000371856
  • ENSP00000360922

Symbol
  • STAU
  • STAU
  • PPP1R150
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.99
interacting protein
0.98
virus perturbation
0.98
cellular component
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2429   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 348   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2429   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 348   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (155)
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.999996331
p_ni:  0.000003669
Score:  0.223
Data Source:  BioPlex,STRINGDB
FBXO11
Tbio
Novelty:  0.02762674
p_int:  0.999913704
p_ni:  0.000086296
Data Source:  BioPlex
NMNAT1
Tbio
Family:  Enzyme
Novelty:  0.01110899
p_int:  0.984720767
p_ni:  0.015279233
Score:  0.71
Data Source:  BioPlex,STRINGDB
ELAVL4
Tbio
Novelty:  0.00260383
p_int:  0.983526793
p_ni:  0.016435381
p_wrong:  0.000037826
Score:  0.572
Data Source:  BioPlex,STRINGDB
RBM34
Tdark
Novelty:  0.58131282
p_int:  0.980679502
p_ni:  0.019320498
Score:  0.558
Data Source:  BioPlex,STRINGDB
STAU2
Tbio
Novelty:  0.03802876
p_int:  0.980341123
p_ni:  0.019658877
Score:  0.679
Data Source:  BioPlex,STRINGDB
RRP8
Tbio
Family:  Enzyme
Novelty:  0.04922797
p_int:  0.973997787
p_ni:  0.026002213
Score:  0.561
Data Source:  BioPlex,STRINGDB
CNBP
Tbio
Novelty:  0.00404247
p_int:  0.969676315
p_ni:  0.030323685
Score:  0.527
Data Source:  BioPlex,STRINGDB
RALY
Tbio
Novelty:  0.03883322
p_int:  0.967808323
p_ni:  0.032191676
p_wrong:  2e-9
Data Source:  BioPlex
PRKRA
Tbio
Family:  Kinase
Novelty:  0.02115618
p_int:  0.964005348
p_ni:  0.035994652
Score:  0.786
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
7
11
5
6.1
97.2
body height
3
3
3
95.5
self reported educational attainment
5
5
4
6.1
95
wellbeing measurement
6
5
6
93.1
electrocardiography
1
1
33
78.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
5
6.1
97.2
body height
3
95.5
self reported educational attainment
4
6.1
95
wellbeing measurement
6
93.1
electrocardiography
33
78.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
staufen double-stranded RNA binding protein 1
VGNC:6274
458319
Macaque
staufen double-stranded RNA binding protein 1
704197
Mouse
MGI:1338864
20853
Rat
RGD:621778
84496
Dog
staufen double-stranded RNA binding protein 1
VGNC:46893
477258
Species
Name
OMA
EggNOG
Inparanoid
Chimp
staufen double-stranded RNA binding protein 1
Macaque
staufen double-stranded RNA binding protein 1
Mouse
Rat
Dog
staufen double-stranded RNA binding protein 1
Publication Statistics
PubMed Score 2429.00
PubMed score by year
PubTator Score 49.31
PubTator score by year
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Related Publications
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PMID
Year
Title