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Tchem
STAT6
Signal transducer and activator of transcription 6

Protein Summary
Description
Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300134
  • ENSP00000300134
  • ENSG00000166888
  • ENST00000454075
  • ENSP00000401486
  • ENST00000537215
  • ENSP00000444530
  • ENST00000538913
  • ENSP00000445409
  • ENST00000543873
  • ENSP00000438451
  • ENST00000556155
  • ENSP00000451742

Symbol
  • STAT6B
  • STAT6C
  • D12S1644
  • IL-4-STAT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological process
0.97
transcription factor perturbation
0.94
biological term
0.91
transcription factor binding site profile
0.9


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1267.23   (req: < 5)
Gene RIFs: 236   (req: <= 3)
Antibodies: 1334   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1267.23   (req: >= 5)
Gene RIFs: 236   (req: > 3)
Antibodies: 1334   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 76
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0