STAT3
Signal transducer and activator of transcription 3
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
chemical | 1 | ||
disease perturbation | 1 | ||
hub protein | 1 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Apoptosis | ||||
Reactome | Association of TriC/CCT with target proteins during biosynthesis | ||||
Reactome | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | ||||
Reactome | Cellular Senescence | ||||
Reactome | Cellular responses to external stimuli | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Apoptosis | ||||
Association of TriC/CCT with target proteins during biosynthesis | ||||
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | ||||
Cellular Senescence | ||||
Cellular responses to external stimuli | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
5 | 5 | 0 | 1.1 | 94.1 | |||||
4 | 4 | 0 | 1.2 | 85.2 | |||||
BMI-adjusted waist-hip ratio | 2 | 5 | 5 | 85.2 | |||||
waist-hip ratio | 1 | 4 | 4 | 75.8 | |||||
1 | 1 | 0 | 1.1 | 74.4 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.1 | 94.1 | |||||
0 | 1.2 | 85.2 | |||||
BMI-adjusted waist-hip ratio | 5 | 85.2 | |||||
waist-hip ratio | 4 | 75.8 | |||||
0 | 1.1 | 74.4 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | signal transducer and activator of transcription 3 | VGNC:9663 | 454682 | |||||
Macaque | signal transducer and activator of transcription 3 | 574128 | ||||||
Mouse | MGI:103038 | 20848 | ||||||
Rat | RGD:3772 | 25125 | ||||||
Dog | signal transducer and activator of transcription 3 | VGNC:46890 | 490967 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | signal transducer and activator of transcription 3 | |||||
Macaque | signal transducer and activator of transcription 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | signal transducer and activator of transcription 3 | |||||
PMID | Year | Title |
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