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Tbio
STARD4
StAR-related lipid transfer protein 4

Protein Summary
Description
May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity). Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD4 (Soccio et al., 2002 [PubMed 12011452]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296632
  • ENSP00000296632
  • ENSG00000164211
  • ENST00000502322
  • ENSP00000427639
  • ENST00000505803
  • ENSP00000427478
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
histone modification site profile
0.83
transcription factor binding site profile
0.83
cell type or tissue
0.72
transcription factor
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.6   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.6   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
STAR
Tbio
Novelty:  0.0012662
Score:  0.926
Data Source:  STRINGDB
STARD3
Tbio
Novelty:  0.01540936
Score:  0.923
Data Source:  STRINGDB
STARD6
Tbio
Novelty:  0.08085975
Score:  0.916
Data Source:  STRINGDB
STARD3NL
Tbio
Novelty:  0.11798896
Score:  0.915
Data Source:  STRINGDB
PCTP
Tbio
Novelty:  0.00801213
Score:  0.8
Data Source:  STRINGDB
SREBF2
Tchem
Family:  TF
Novelty:  0.00171709
Score:  0.7
Data Source:  STRINGDB
SH3GL1
Tbio
Novelty:  0.02379336
Score:  0.655
Data Source:  STRINGDB
FGFR1OP2
Tbio
Novelty:  0.1082136
Score:  0.647
Data Source:  STRINGDB
MSMO1
Tbio
Family:  Enzyme
Novelty:  0.01263528
Score:  0.596
Data Source:  STRINGDB
STARD13
Tbio
Novelty:  0.00750938
Score:  0.577
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroid hormones
Reactome
Metabolism of steroids
Reactome
Pregnenolone biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Metabolism of steroid hormones
Metabolism of steroids
Pregnenolone biosynthesis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
1
3
66.4
autoimmune thyroid disease
1
1
0
1.1
58.5
age at menarche
1
1
1
57
lymphocyte percentage of leukocytes
1
1
1
50
blood protein measurement
1
1
1
41.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
66.4
autoimmune thyroid disease
0
1.1
58.5
age at menarche
1
57
lymphocyte percentage of leukocytes
1
50
blood protein measurement
1
41.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
StAR related lipid transfer domain containing 4
706654
Mouse
MGI:2156764
170459
Rat
RGD:1309475
291699
Dog
StAR related lipid transfer domain containing 4
VGNC:46884
479141
Horse
StAR related lipid transfer domain containing 4
VGNC:23659
100073191
Species
Name
OMA
EggNOG
Inparanoid
Macaque
StAR related lipid transfer domain containing 4
Mouse
Rat
Dog
StAR related lipid transfer domain containing 4
Horse
StAR related lipid transfer domain containing 4
Publication Statistics
PubMed Score 21.60
PubMed score by year
PubTator Score 14.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title