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Tbio
STARD3NL
STARD3 N-terminal-like protein

Protein Summary
Description
Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263). This gene encodes a late-endosomal protein that contains a conserved MENTAL (MLN64 N-terminal) domain. The encoded protein binds cholesterol molecules and may play a role in endosomal cholesterol transport through interactions with metastatic lymph node protein 64 (MLN64). [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000009041
  • ENSP00000009041
  • ENSG00000010270
  • ENST00000396013
  • ENSP00000379334

Symbol
  • MENTHO
  • MENTHO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
transcription factor binding site profile
0.75
cell type or tissue
0.73
virus perturbation
0.68
tissue sample
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.02   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 20   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.02   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 20   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
STAR
Tbio
Novelty:  0.0012662
Score:  0.969
Data Source:  Reactome,STRINGDB
STARD4
Tbio
Novelty:  0.05932371
Score:  0.915
Data Source:  STRINGDB
STARD3
Tbio
Novelty:  0.01540936
Score:  0.904
Data Source:  Reactome,STRINGDB
STARD6
Tbio
Novelty:  0.08085975
Score:  0.9
Data Source:  STRINGDB
NPC2
Tbio
Novelty:  0.00342898
Score:  0.9
Data Source:  STRINGDB
EPDR1
Tbio
Novelty:  0.03597825
Score:  0.806
Data Source:  STRINGDB
HECW1
Tbio
Family:  Enzyme
Novelty:  0.15200354
Score:  0.717
Data Source:  STRINGDB
TOX4
Tbio
Family:  TF
Novelty:  0.02486844
Score:  0.714
Data Source:  STRINGDB
AMPH
Tbio
Novelty:  0.00201043
Score:  0.671
Data Source:  STRINGDB
DCDC1
Tbio
Novelty:  0.21703566
Score:  0.669
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroid hormones
Reactome
Metabolism of steroids
Reactome
Pregnenolone biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Metabolism of steroid hormones
Metabolism of steroids
Pregnenolone biosynthesis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
5
5
7
95.1
heel bone mineral density
2
4
4
88.2
blood protein measurement
2
2
2
79
high density lipoprotein cholesterol measurement
5
3
5
73
2
2
1
1
55.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
7
95.1
heel bone mineral density
4
88.2
blood protein measurement
2
79
high density lipoprotein cholesterol measurement
5
73
1
1
55.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
STARD3 N-terminal like
VGNC:14092
463358
Macaque
STARD3 N-terminal like
705212
Mouse
MGI:1923455
76205
Rat
RGD:1308633
291182
Dog
STARD3 N-terminal like
VGNC:46883
483257
Species
Name
OMA
EggNOG
Inparanoid
Chimp
STARD3 N-terminal like
Macaque
STARD3 N-terminal like
Mouse
Rat
Dog
STARD3 N-terminal like
Publication Statistics
PubMed Score 12.02
PubMed score by year
PubTator Score 4.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title