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Tbio
STAR
Steroidogenic acute regulatory protein, mitochondrial

Protein Summary
Description
Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276449
  • ENSP00000276449
  • ENSG00000147465

Symbol
  • STARD1
  • STARD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
0.98
gene perturbation
0.83
biological term
0.75
disease perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 884.87   (req: < 5)
Gene RIFs: 89   (req: <= 3)
Antibodies: 286   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 884.87   (req: >= 5)
Gene RIFs: 89   (req: > 3)
Antibodies: 286   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 53
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
CYP11A1
Tclin
Family:  Enzyme
Novelty:  0.00096368
Score:  0.994
Data Source:  STRINGDB
FDX1
Tbio
Novelty:  0.00124491
Score:  0.97
Data Source:  STRINGDB
STARD3NL
Tbio
Novelty:  0.11798896
Score:  0.969
Data Source:  Reactome,STRINGDB
FDXR
Tbio
Family:  Enzyme
Novelty:  0.00171588
Score:  0.951
Data Source:  STRINGDB
VDAC1
Tbio
Novelty:  0.0011441
Score:  0.927
Data Source:  STRINGDB
STARD4
Tbio
Novelty:  0.05932371
Score:  0.926
Data Source:  STRINGDB
VDAC2
Tchem
Novelty:  0.00575936
Score:  0.923
Data Source:  STRINGDB
STARD6
Tbio
Novelty:  0.08085975
Score:  0.92
Data Source:  STRINGDB
STARD3
Tbio
Novelty:  0.01540936
Score:  0.913
Data Source:  Reactome,STRINGDB
FDX2
Tdark
Novelty:  0.05747769
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (64)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroid hormones
Reactome
Metabolism of steroids
Reactome
Pregnenolone biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Metabolism of steroid hormones
Metabolism of steroids
Pregnenolone biosynthesis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
2
2
93.6
schizophrenia
1
1
0
1.2
70.2
urate measurement
1
1
1
62.4
1
1
0
7.2
59.7
diastolic blood pressure
1
1
1
40.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
93.6
schizophrenia
0
1.2
70.2
urate measurement
1
62.4
0
7.2
59.7
diastolic blood pressure
1
40.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
steroidogenic acute regulatory protein
VGNC:788
746738
Macaque
steroidogenic acute regulatory protein
699515
Mouse
MGI:102760
20845
Rat
RGD:3770
25557
Dog
steroidogenic acute regulatory protein
VGNC:46880
475588
Species
Name
OMA
EggNOG
Inparanoid
Chimp
steroidogenic acute regulatory protein
Macaque
steroidogenic acute regulatory protein
Mouse
Rat
Dog
steroidogenic acute regulatory protein
Publication Statistics
PubMed Score 884.87
PubMed score by year
PubTator Score 907.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title