STAP2
Signal-transducing adaptor protein 2
Protein Summary
Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity. This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
- ENST00000594605
- ENSP00000471052
- ENSG00000178078
- ENST00000600324
- ENSP00000468927
- BKS
- BKS
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.74 | ||
tissue sample | 0.67 | ||
transcription factor | 0.63 | ||
tissue | 0.52 | ||
cellular component | 0.51 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 245.82 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 278 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 245.82 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 278 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (43)
PADI1
Family: Enzyme
Novelty: 0.01388854
p_int: 0.999999972
p_ni: 2.8e-8
Score: 0.692
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | PTK6 Activates STAT3 | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by Non-Receptor Tyrosine Kinases | ||||
Reactome | Signaling by PTK6 | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
PTK6 Activates STAT3 | ||||
Signal Transduction | ||||
Signaling by Non-Receptor Tyrosine Kinases | ||||
Signaling by PTK6 | ||||
Viral Interactions (0)
Gene Ontology Terms (4)
Functions (1)
Components (2)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
interleukin-27 measurement | 1 | 3 | 3 | 97.1 | |||||
red blood cell distribution width | 4 | 3 | 5 | 96.6 | |||||
blood protein measurement | 1 | 1 | 1 | 87.5 | |||||
hematocrit | 2 | 1 | 2 | 77 | |||||
self reported educational attainment | 1 | 1 | 1 | 69.4 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
interleukin-27 measurement | 3 | 97.1 | |||||
red blood cell distribution width | 5 | 96.6 | |||||
blood protein measurement | 1 | 87.5 | |||||
hematocrit | 2 | 77 | |||||
self reported educational attainment | 1 | 69.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:2147039 | 106766 | ||||||
Rat | RGD:1566020 | 363334 | ||||||
Dog | signal transducing adaptor family member 2 | VGNC:46879 | 485041 | |||||
Cow | signal transducing adaptor family member 2 | VGNC:35359 | 505456 | |||||
Opossum | signal transducing adaptor family member 2 | 100022851 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | signal transducing adaptor family member 2 | |||||
Cow | signal transducing adaptor family member 2 | |||||
Opossum | signal transducing adaptor family member 2 | |||||
Publication Statistics
PubMed Score 245.82
PubMed score by year
PubTator Score 6.82
PubTator score by year
Related Publications
Text Mined References (24)
GeneRif Annotations (15)
Items per page:
0 of 0
PMID | Year | Title |
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