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Tbio
STAM
Signal transducing adapter molecule 1

Protein Summary
Description
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane protein ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377524
  • ENSP00000366746
  • ENSG00000136738

Symbol
  • STAM1
  • STAM1
  • STAM-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
kinase perturbation
0.96
interacting protein
0.92
histone modification site profile
0.82
transcription factor perturbation
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.26   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 315   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.26   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 315   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (218)
HGS
Tbio
Family:  Enzyme
Novelty:  0.00665044
p_int:  1
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
TRAF7
Tbio
Family:  Enzyme
Novelty:  0.02437761
p_int:  0.985238624
p_ni:  0.014761375
p_wrong:  1e-9
Score:  0.167
Data Source:  BioPlex,STRINGDB
NCEH1
Tchem
Family:  Enzyme
Novelty:  0.01528589
p_int:  0.980936456
p_ni:  0.018293593
p_wrong:  0.000769951
Score:  0.173
Data Source:  BioPlex,STRINGDB
SNX1
Tbio
Novelty:  0.01267973
p_int:  0.767232784
p_ni:  0.203368634
p_wrong:  0.029398582
Score:  0.593
Data Source:  BioPlex,STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.997
Data Source:  STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.996
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.995
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.995
Data Source:  STRINGDB
STAMBP
Tchem
Novelty:  0.01543821
Score:  0.992
Data Source:  Reactome,STRINGDB
UBQLN2
Tbio
Novelty:  0.00776132
Score:  0.985
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 4 of 4
JAK2
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
JAK3
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
JAK1
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
TYK2
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
Pathways (29)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

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Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Deubiquitination
Reactome
Disease
Reactome
EGFR downregulation
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Deubiquitination
Disease
EGFR downregulation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
2
2
50.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
50.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
signal transducing adaptor molecule
VGNC:5790
466269
Macaque
signal transducing adaptor molecule
706026
Mouse
MGI:1329014
20844
Rat
RGD:1564499
498798
Dog
signal transducing adaptor molecule
VGNC:46875
477990
Species
Name
OMA
EggNOG
Inparanoid
Chimp
signal transducing adaptor molecule
Macaque
signal transducing adaptor molecule
Mouse
Rat
Dog
signal transducing adaptor molecule
Publication Statistics
PubMed Score 24.26
PubMed score by year
PubTator Score 70.51
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title