Tbio STAG1 Cohesin subunit SA-1

Protein Summary

Description

Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8WVM7
• O00539
• Q6P275

Gene Name

• STAG1

Ensembl ID

• ENST00000236698
• ENSP00000236698
• ENSG00000118007
• ENST00000383202
• ENSP00000372689

Symbol

• SA1
• SCC3
• SA1
• MRD47
• SCC3A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.98
interacting protein	0.97
kinase perturbation	0.95
transcription factor perturbation	0.91
transcription factor	0.75

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Cohesin Subunit Sa-1

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Cohesin Subunit Sa-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1242.16   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 239   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1242.16   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0