Protein Summary
Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS. This gene encodes a large, tran ...more
- ENST00000388887
- ENSP00000373539
- ENSG00000136011
- FEEL2
- FELL
- FEX2
- HARE
- FEX2
- HARE
- FEEL2
- FELL2
- FELE-2
- SCARH1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
pathway | 0.94 | ||
trait | 0.86 | ||
molecular function | 0.73 | ||
cell type or tissue | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 87.86 (req: < 5)
Gene RIFs: 27 (req: <= 3)
Antibodies: 124 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 87.86 (req: >= 5)
Gene RIFs: 27 (req: > 3)
Antibodies: 124 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (56)
Nearest Tclin Targets
Pathways (8)
Reactome (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Binding and Uptake of Ligands by Scavenger Receptors | ||||
Reactome | Glycosaminoglycan metabolism | ||||
Reactome | Hyaluronan metabolism | ||||
Reactome | Hyaluronan uptake and degradation | ||||
Reactome | Metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Binding and Uptake of Ligands by Scavenger Receptors | ||||
Glycosaminoglycan metabolism | ||||
Hyaluronan metabolism | ||||
Hyaluronan uptake and degradation | ||||
Metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (6)
Components (5)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
von Willebrand factor measurement | 3 | 1 | 2 | 2.4 | 82.7 | ||||
factor VIII measurement | 1 | 1 | 2 | 72.6 | |||||
Thyroid preparation use measurement | 1 | 1 | 1 | 54.4 | |||||
monocyte count | 1 | 1 | 1 | 52.7 | |||||
response to drug | 1 | 1 | 0 | 4 | 21.5 | ||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
von Willebrand factor measurement | 2 | 2.4 | 82.7 | ||||
factor VIII measurement | 2 | 72.6 | |||||
Thyroid preparation use measurement | 1 | 54.4 | |||||
monocyte count | 1 | 52.7 | |||||
response to drug | 0 | 4 | 21.5 | ||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | stabilin 2 | VGNC:5602 | 452186 | |||||
Mouse | MGI:2178743 | 192188 | ||||||
Rat | RGD:628822 | 282580 | ||||||
Dog | stabilin 2 | VGNC:46869 | 100687903 | |||||
Horse | stabilin 2 | VGNC:23645 | 100067500 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | stabilin 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | stabilin 2 | |||||
Horse | stabilin 2 | |||||
Publication Statistics
PubMed Score 87.86
PubMed score by year
PubTator Score 53.85
PubTator score by year
Related Publications
Text Mined References (38)
GeneRif Annotations (27)
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0 of 0
PMID | Year | Title |
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