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Tbio
STAB1
Stabilin-1

Protein Summary
Description
Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system. This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacte ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321725
  • ENSP00000312946
  • ENSG00000010327

Symbol
  • FEEL1
  • KIAA0246
  • FEX1
  • FEEL-1
  • FELE-1
  • SCARH2
  • STAB-1
  • CLEVER-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
interacting protein
0.73
molecular function
0.73
disease perturbation
0.68
cellular component
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.27   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.27   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
SPARC
Tbio
Novelty:  0.00063267
Score:  0.929
Data Source:  Reactome,STRINGDB
APOB
Tchem
Novelty:  0.00008247
Score:  0.906
Data Source:  STRINGDB
CHID1
Tbio
Family:  Enzyme
Novelty:  0.07886935
Score:  0.867
Data Source:  STRINGDB
CD163
Tbio
Novelty:  0.0007415
Score:  0.746
Data Source:  STRINGDB
C1QA
Tbio
Novelty:  0.00987917
Score:  0.736
Data Source:  STRINGDB
C1QB
Tbio
Novelty:  0.01476497
Score:  0.718
Data Source:  STRINGDB
CD14
Tbio
Novelty:  0.00872424
Score:  0.709
Data Source:  STRINGDB
SCARF1
Tbio
Novelty:  0.00938046
Score:  0.705
Data Source:  STRINGDB
C1QC
Tbio
Novelty:  0.0286777
Score:  0.687
Data Source:  STRINGDB
MRC1
Tbio
Novelty:  0.00104675
Score:  0.68
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Scavenging by Class H Receptors
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors
Scavenging by Class H Receptors
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
12
16
34
97.8
triglyceride measurement
2
3
3
93
high density lipoprotein cholesterol measurement
5
5
7
91.9
waist-hip ratio
4
13
15
91.7
hematocrit
3
2
3
88.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
34
97.8
triglyceride measurement
3
93
high density lipoprotein cholesterol measurement
7
91.9
waist-hip ratio
15
91.7
hematocrit
3
88.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2178742
192187
Rat
RGD:2324745
100363145
Dog
stabilin 1
VGNC:54368
100856645
Horse
stabilin 1
VGNC:23644
100060121
Cow
stabilin 1
VGNC:35348
505543
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
stabilin 1
Horse
stabilin 1
Cow
stabilin 1
Publication Statistics
PubMed Score 89.27
PubMed score by year
PubTator Score 47.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title