Tdark ST8SIA5 Alpha-2,8-sialyltransferase 8E

Protein Summary

Description

May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively. The protein encoded by this gene is a type II membrane protein that may be present in the Golgi apparatus. The encoded protein, which is a member of glycosyltransferase family 29, may be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b, and GT3 from GD1a, GT1b, GM1b, and GD3, respectively. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O15466
• B7Z1K9
• Q6IAW7

Gene Name

• ST8SIA5

Ensembl ID

• ENST00000315087
• ENSP00000321343
• ENSG00000101638
• ENST00000538168
• ENSP00000445492

Symbol

• SIAT8E
• SIAT8E
• SIAT8-E
• ST8SiaV

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.64
PubMedID	0.6
histone modification site profile	0.56
cellular component	0.52
pathway	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.88   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 35   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.88   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0