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Tbio
ST8SIA4
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

Protein Summary
Description
Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells. The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231461
  • ENSP00000231461
  • ENSG00000113532
  • ENST00000451528
  • ENSP00000428914

Symbol
  • PST
  • PST1
  • SIAT8D
  • PST
  • PST1
  • SIAT8D
  • ST8SIA-IV
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
PubMedID
0.87
pathway
0.86
microRNA
0.74
cellular component
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 263.83   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 263.83   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (122)
DNASE1L1
Tbio
Family:  Enzyme
Novelty:  0.03020646
p_int:  0.999896271
p_ni:  0.000012206
p_wrong:  0.000091523
Data Source:  BioPlex
SUSD1
Tdark
Novelty:  0.54249826
p_int:  0.999466985
p_ni:  0.000533015
Data Source:  BioPlex
ITGA7
Tbio
Novelty:  0.01243073
p_int:  0.999081442
p_ni:  0.000918558
Data Source:  BioPlex
TGFBR3
Tbio
Novelty:  0.0077307
p_int:  0.998194983
p_ni:  0.001796844
p_wrong:  0.000008173
Data Source:  BioPlex
PTCH1
Tbio
Novelty:  0.00077635
p_int:  0.998004386
p_ni:  0.00111171
p_wrong:  0.000883904
Score:  0.181
Data Source:  BioPlex,STRINGDB
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.9977694
p_ni:  0.001205895
p_wrong:  0.001024704
Data Source:  BioPlex
ADAMTS2
Tbio
Family:  Enzyme
Novelty:  0.00852208
p_int:  0.997467115
p_ni:  0.002532879
p_wrong:  6e-9
Data Source:  BioPlex
RNASEL
Tchem
Family:  Kinase
Novelty:  0.00165549
p_int:  0.997226322
p_ni:  0.002773265
p_wrong:  4.13e-7
Data Source:  BioPlex
SEMA4D
Tbio
Novelty:  0.0043592
p_int:  0.996746675
p_ni:  0.001443269
p_wrong:  0.001810055
Score:  0.278
Data Source:  BioPlex,STRINGDB
PLXNA2
Tbio
Novelty:  0.01765957
p_int:  0.996137812
p_ni:  0.003862188
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Axon guidance
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Developmental Biology
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Axon guidance
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Developmental Biology
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
61.4
monocyte count
1
1
1
46.9
leukocyte count
1
1
1
38.8
2
2
0
1.1
32.8
neutrophil count
1
1
1
12.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
61.4
monocyte count
1
46.9
leukocyte count
1
38.8
0
1.1
32.8
neutrophil count
1
12.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
702400
Mouse
MGI:106018
20452
Rat
RGD:621845
116696
Dog
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
VGNC:46866
488886
Horse
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
VGNC:23641
100064780
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
Mouse
Rat
Dog
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
Horse
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
Publication Statistics
PubMed Score 263.83
PubMed score by year
PubTator Score 111.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title