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Tbio
ST8SIA1
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

Protein Summary
Description
Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid. Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261197
  • ENSP00000261197
  • ENSG00000111728
  • ENST00000396037
  • ENSP00000379353

Symbol
  • SIAT8
  • SIAT8A
  • GD3S
  • SIAT8
  • SIAT8A
  • SIAT8-A
  • ST8SiaI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.92
co-expressed gene
0.89
PubMedID
0.78
cell type or tissue
0.77
transcription factor binding site profile
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.83   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.83   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
RPIA
Tbio
Family:  Enzyme
Novelty:  0.00968705
p_int:  0.999518409
p_ni:  0.000481588
p_wrong:  3e-9
Score:  0.196
Data Source:  BioPlex,STRINGDB
NMD3
Tbio
Novelty:  0.03505289
p_int:  0.999284968
p_ni:  0.000715031
p_wrong:  2e-9
Score:  0.787
Data Source:  BioPlex,STRINGDB
HOOK2
Tbio
Novelty:  0.03559628
p_int:  0.99290407
p_ni:  0.007095928
p_wrong:  2e-9
Score:  0.193
Data Source:  BioPlex,STRINGDB
RUFY1
Tbio
Novelty:  0.16796947
p_int:  0.945247493
p_ni:  0.054173322
p_wrong:  0.000579185
Score:  0.187
Data Source:  BioPlex,STRINGDB
IPO13
Tbio
Novelty:  0.01954093
p_int:  0.94332796
p_ni:  0.05667204
Score:  0.189
Data Source:  BioPlex,STRINGDB
POTEF
Tbio
Novelty:  0.00191599
p_int:  0.841206129
p_ni:  0.158793871
Score:  0.16
Data Source:  BioPlex,STRINGDB
INTS12
Tbio
Family:  Epigenetic
Novelty:  0.09023473
p_int:  0.786739776
p_ni:  0.213260217
p_wrong:  7e-9
Score:  0.193
Data Source:  BioPlex,STRINGDB
ZMYM2
Tbio
Novelty:  0.0258698
p_int:  0.757795302
p_ni:  0.242204698
Score:  0.193
Data Source:  BioPlex,STRINGDB
B4GALNT1
Tbio
Family:  Enzyme
Novelty:  0.01060447
Score:  0.974
Data Source:  STRINGDB
ST3GAL5
Tbio
Family:  Enzyme
Novelty:  0.01407498
Score:  0.964
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Sialic acid metabolism
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
Post-translational protein modification
Sialic acid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
1
2
64.1
platelet crit
1
1
1
60.3
smoking status measurement
1
1
1
17.7
high density lipoprotein cholesterol measurement
1
1
1
15.1
age at onset
1
1
0
6.1
10.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
64.1
platelet crit
1
60.3
smoking status measurement
1
17.7
high density lipoprotein cholesterol measurement
1
15.1
age at onset
0
6.1
10.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
706707
Mouse
MGI:106011
20449
Rat
RGD:3679
25280
Dog
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
VGNC:46864
477672
Horse
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
VGNC:23640
100064415
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
Mouse
Rat
Dog
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
Horse
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
Publication Statistics
PubMed Score 58.83
PubMed score by year
PubTator Score 24.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title