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Tbio
ST7L
Suppressor of tumorigenicity 7 protein-like

Protein Summary
Description
This gene was identified by its similarity to the ST7 tumor suppressor gene found in the chromosome 7q31 region. This gene is clustered in a tail-to-tail manner with the WNT2B gene in a chromosomal region known to be deleted and rearranged in a variety of cancers. Several transcript variants encoding many different isoforms have been described, but some have not been fully characterized. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343210
  • ENSP00000345312
  • ENSG00000007341
  • ENST00000358039
  • ENSP00000350734
  • ENST00000360743
  • ENSP00000353972
  • ENST00000361846
  • ENSP00000436499
  • ENST00000369666
  • ENSP00000358680
  • ENST00000369669
  • ENSP00000358683
  • ENST00000490067
  • ENSP00000417140
  • ENST00000490715
  • ENSP00000436544

Symbol
  • ST7R
  • ST7R
  • STLR
  • FAM4B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
transcription factor binding site profile
0.74
transcription factor perturbation
0.74
cell type or tissue
0.69
microRNA
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.94   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 32   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.94   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.999442367
p_ni:  0.000557633
Data Source:  BioPlex
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.998960166
p_ni:  0.001035352
p_wrong:  0.000004482
Data Source:  BioPlex
FAM189B
Tbio
Novelty:  0.21064304
p_int:  0.998297078
p_ni:  0.001701063
p_wrong:  0.000001859
Data Source:  BioPlex
PCDHB11
Tdark
Novelty:  0.80480462
p_int:  0.99728934
p_ni:  0.002710566
p_wrong:  9.4e-8
Data Source:  BioPlex
CHRND
Tclin
Family:  IC
Novelty:  0.0441685
p_int:  0.997179838
p_ni:  0.002820158
p_wrong:  4e-9
Data Source:  BioPlex
PTCHD3
Tbio
Novelty:  0.00081643
p_int:  0.995872068
p_ni:  0.003978418
p_wrong:  0.000149514
Data Source:  BioPlex
KCNS3
Tclin
Family:  IC
Novelty:  0.05882087
p_int:  0.992004921
p_ni:  0.006966345
p_wrong:  0.001028734
Data Source:  BioPlex
SLC17A2
Tdark
Family:  Transporter
Novelty:  0.23941275
p_int:  0.989521293
p_ni:  0.010478706
p_wrong:  1e-9
Data Source:  BioPlex
PCDHGB4
Tdark
Novelty:  0.25018904
p_int:  0.987093094
p_ni:  0.012906902
p_wrong:  4e-9
Data Source:  BioPlex
PCDHB7
Tdark
Novelty:  0.60789936
p_int:  0.986947444
p_ni:  0.011766721
p_wrong:  0.001285834
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (35)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
6
5
6
8.1
96.9
heel bone mineral density
3
3
6
96
mean platelet volume
3
3
3
94
creatinine measurement
2
2
2
92.5
platelet count
2
2
2
91.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
6
8.1
96.9
heel bone mineral density
6
96
mean platelet volume
3
94
creatinine measurement
2
92.5
platelet count
2
91.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
suppression of tumorigenicity 7 like
VGNC:8510
457102
Macaque
suppression of tumorigenicity 7 like
705541
Mouse
MGI:2386964
229681
Rat
RGD:1359336
295344
Dog
suppression of tumorigenicity 7 like
VGNC:46863
612836
Species
Name
OMA
EggNOG
Inparanoid
Chimp
suppression of tumorigenicity 7 like
Macaque
suppression of tumorigenicity 7 like
Mouse
Rat
Dog
suppression of tumorigenicity 7 like
Publication Statistics
PubMed Score 31.94
PubMed score by year
PubTator Score 10.77
PubTator score by year
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Related Publications
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PMID
Year
Title