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Tbio
ST6GALNAC5
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5

Protein Summary
Description
Involved in the biosynthesis of ganglioside GD1a from GM1b. It exhibits higher activity with glycolipids than with glycoproteins (By similarity). The protein encoded by this gene is a Golgi type II transmembrane glycosyltransferase. The encoded protein catalyzes the transfer of sialic acid to cell surface proteins to modulate cell-cell interactions. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000477717
  • ENSP00000417583
  • ENSG00000117069

Symbol
  • SIAT7E
  • SIAT7E
  • SIAT7-E
  • ST6GalNAcV
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.77
tissue sample
0.68
gene perturbation
0.59
cell line
0.54
cellular component
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.08   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.08   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
FBP1
Tchem
Family:  Enzyme
Novelty:  0.0029987
p_int:  0.999998849
p_ni:  0.000001145
p_wrong:  6e-9
Score:  0.516
Data Source:  BioPlex,STRINGDB
FBXO2
Tbio
Novelty:  0.01578361
p_int:  0.920277993
p_ni:  0.079608045
p_wrong:  0.000113963
Score:  0.326
Data Source:  BioPlex,STRINGDB
ST8SIA5
Tdark
Family:  Enzyme
Novelty:  0.19468906
Score:  0.944
Data Source:  STRINGDB
ST3GAL1
Tchem
Family:  Enzyme
Novelty:  0.01236776
Score:  0.916
Data Source:  STRINGDB
ST3GAL2
Tbio
Family:  Enzyme
Novelty:  0.03503891
Score:  0.915
Data Source:  STRINGDB
ST6GALNAC3
Tbio
Family:  Enzyme
Novelty:  0.09030057
Score:  0.807
Data Source:  STRINGDB
ST6GALNAC4
Tbio
Family:  Enzyme
Novelty:  0.08976097
Score:  0.805
Data Source:  STRINGDB
LGALS7
Tbio
Novelty:  0.00753996
Score:  0.67
Data Source:  STRINGDB
NANS
Tbio
Family:  Enzyme
Novelty:  0.00718044
Score:  0.599
Data Source:  STRINGDB
CDH2
Tbio
Novelty:  0.00040112
Score:  0.596
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Sialic acid metabolism
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
Post-translational protein modification
Sialic acid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
0
1.1
80.8
educational attainment
1
1
1
43.2
gut microbiome measurement
1
1
1
23.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
0
1.1
80.8
educational attainment
1
43.2
gut microbiome measurement
1
23.7
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
VGNC:10960
456960
Macaque
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
705908
Mouse
MGI:1349471
26938
Dog
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
VGNC:46861
613015
Horse
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 [Source:HGNC Symbol;Acc:HGNC:19342]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
Macaque
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
Mouse
Dog
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
Horse
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 [Source:HGNC Symbol;Acc:HGNC:19342]
Publication Statistics
PubMed Score 26.08
PubMed score by year
PubTator Score 9.41
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title