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Tbio
ST6GALNAC4
Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase

Protein Summary
Description
Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. Prefers glycoproteins to glycolipids (By similarity). The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein prefers glycoproteins rather than glycolipids as substrates and shows restricted substrate specificity, utilizing only the trisaccharide sequence Neu5Ac-alpha-2,3-Gal-beta-1,3-GalNAc. In addition, it is involved in the synthesis of ganglioside GD1A from GM1B. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335791
  • ENSP00000336733
  • ENSG00000136840

Symbol
  • SIAT3C
  • SIAT7D
  • IV
  • SIAT3C
  • SIAT7D
  • SIAT3-C
  • SIAT7-D
  • ST6GalNAc
  • ST6GALNACIV
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
transcription factor perturbation
0.8
histone modification site profile
0.65
cell line
0.6
virus perturbation
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.02   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.02   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (103)
HFE
Tbio
Novelty:  0.00042077
p_int:  0.998795109
p_ni:  0.000599188
p_wrong:  0.000605703
Data Source:  BioPlex
HLA-DRA
Tbio
Novelty:  0.0060214
p_int:  0.957910493
p_ni:  0.00389191
p_wrong:  0.038197597
Data Source:  BioPlex
KLRG2
Tdark
Novelty:  1.19446694
p_int:  0.924083271
p_ni:  0.000481085
p_wrong:  0.075435644
Score:  0.189
Data Source:  BioPlex,STRINGDB
VTN
Tbio
Family:  TF
Novelty:  0.00046861
p_int:  0.758078762
p_ni:  0.000080707
p_wrong:  0.241840531
Score:  0.189
Data Source:  BioPlex,STRINGDB
MUC1
Tchem
Novelty:  0.00024203
Score:  0.945
Data Source:  STRINGDB
MUC16
Tbio
Novelty:  0.00444587
Score:  0.931
Data Source:  STRINGDB
MUC4
Tbio
Novelty:  0.00193208
Score:  0.929
Data Source:  STRINGDB
MUC5AC
Tbio
Novelty:  0.00074159
Score:  0.922
Data Source:  STRINGDB
ST3GAL1
Tchem
Family:  Enzyme
Novelty:  0.01236776
Score:  0.922
Data Source:  STRINGDB
MUC5B
Tbio
Novelty:  0.000832
Score:  0.921
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Asparagine N-linked glycosylation (R-HSA-446203)

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Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
O-linked glycosylation
Reactome
O-linked glycosylation of mucins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
O-linked glycosylation
O-linked glycosylation of mucins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
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Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
3
3
93.9
hematocrit
3
2
3
86.8
urate measurement
3
3
3
76.4
monocyte count
2
2
2
70.8
red blood cell density measurement
1
1
1
43.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
93.9
hematocrit
3
86.8
urate measurement
3
76.4
monocyte count
2
70.8
red blood cell density measurement
1
43.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
VGNC:10109
450108
Macaque
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
705879
Mouse
MGI:1341894
20448
Dog
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
VGNC:46860
609133
Horse
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
VGNC:23637
100067121
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
Macaque
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
Mouse
Dog
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
Horse
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
Publication Statistics
PubMed Score 9.02
PubMed score by year
PubTator Score 5.64
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title