ST6GALNAC1
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Protein Summary
Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al., 1999 [PubMed 10536037]; Sewell et al., 2006 [PubMed 16319059]).[supplied by OMIM, Mar 2008]
- ENST00000156626
- ENSP00000156626
- ENSG00000070526
- SIAT7A
- STYI
- SIAT7A
- HSY11339
- ST6GalNAcI
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue sample | 0.62 | ||
tissue | 0.56 | ||
virus perturbation | 0.55 | ||
cellular component | 0.54 | ||
pathway | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 188.5 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 127 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 188.5 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 127 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (96)
EEF1A2
Novelty: 0.001472
p_int: 0.817084938
p_ni: 0.182915061
Score: 0.8
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (10)
Reactome (6)
KEGG (2)
UniProt (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Reactome | Sialic acid metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Asparagine N-linked glycosylation | ||||
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Metabolism of proteins | ||||
Post-translational protein modification | ||||
Sialic acid metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Functions (2)
Components (2)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
neutrophil count | 2 | 1 | 2 | 63.7 | |||||
pulse pressure measurement | 1 | 1 | 1 | 51.7 | |||||
mathematical ability | 1 | 1 | 1 | 21.5 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
neutrophil count | 2 | 63.7 | |||||
pulse pressure measurement | 1 | 51.7 | |||||
mathematical ability | 1 | 21.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 | VGNC:9660 | 449516 | |||||
Macaque | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 | 707339 | ||||||
Mouse | MGI:1341826 | 20445 | ||||||
Rat | RGD:1562048 | 287920 | ||||||
Dog | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 | VGNC:46858 | 100049002 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 | |||||
Macaque | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 | |||||
Publication Statistics
PubMed Score 188.50
PubMed score by year
PubTator Score 63.36
PubTator score by year
Related Publications
Text Mined References (19)
GeneRif Annotations (10)
Items per page:
0 of 0
PMID | Year | Title |
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