You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ST6GALNAC1
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1

Protein Summary
Description
Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al., 1999 [PubMed 10536037]; Sewell et al., 2006 [PubMed 16319059]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000156626
  • ENSP00000156626
  • ENSG00000070526

Symbol
  • SIAT7A
  • STYI
  • SIAT7A
  • HSY11339
  • ST6GalNAcI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.62
tissue
0.56
virus perturbation
0.55
cellular component
0.54
pathway
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.5   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.5   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (96)
EEF1A2
Tchem
Novelty:  0.001472
p_int:  0.817084938
p_ni:  0.182915061
Score:  0.8
Data Source:  BioPlex,STRINGDB
C1GALT1
Tbio
Family:  Enzyme
Novelty:  0.01191596
Score:  0.97
Data Source:  STRINGDB
C1GALT1C1
Tbio
Family:  Enzyme
Novelty:  0.01318017
Score:  0.969
Data Source:  STRINGDB
GCNT1
Tbio
Family:  Enzyme
Novelty:  0.01487872
Score:  0.966
Data Source:  STRINGDB
B3GNT6
Tbio
Family:  Enzyme
Novelty:  0.13176407
Score:  0.949
Data Source:  STRINGDB
ST3GAL1
Tchem
Family:  Enzyme
Novelty:  0.01236776
Score:  0.927
Data Source:  STRINGDB
ST3GAL2
Tbio
Family:  Enzyme
Novelty:  0.03503891
Score:  0.919
Data Source:  STRINGDB
GALNT2
Tchem
Family:  Enzyme
Novelty:  0.02458542
Score:  0.874
Data Source:  STRINGDB
GALNT6
Tbio
Family:  Enzyme
Novelty:  0.04627605
Score:  0.857
Data Source:  STRINGDB
GALNT3
Tbio
Family:  Enzyme
Novelty:  0.01140808
Score:  0.83
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Sialic acid metabolism
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
Post-translational protein modification
Sialic acid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
1
2
63.7
pulse pressure measurement
1
1
1
51.7
mathematical ability
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
63.7
pulse pressure measurement
1
51.7
mathematical ability
1
21.5
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
VGNC:9660
449516
Macaque
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
707339
Mouse
MGI:1341826
20445
Rat
RGD:1562048
287920
Dog
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
VGNC:46858
100049002
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Macaque
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Mouse
Rat
Dog
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Publication Statistics
PubMed Score 188.50
PubMed score by year
PubTator Score 63.36
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title