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Tbio
ST6GAL2
Beta-galactoside alpha-2,6-sialyltransferase 2

Protein Summary
Description
Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids. This locus encodes a sialyltransferase. The encoded type II transmembrane protein catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. Polymorphisms at this locus may be associated with variations in risperidone response in schizophrenic patients. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361686
  • ENSP00000355273
  • ENSG00000144057
  • ENST00000409087
  • ENSP00000387332
  • ENST00000409382
  • ENSP00000386942

Symbol
  • KIAA1877
  • SIAT2
  • SIAT2
  • ST6GalII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.9
microRNA
0.81
cell type or tissue
0.68
phenotype
0.59
transcription factor
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.3   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.3   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
B4GALT1
Tbio
Family:  Enzyme
Novelty:  0.0073693
Score:  0.971
Data Source:  STRINGDB
B4GALT2
Tbio
Family:  Enzyme
Novelty:  0.03492512
Score:  0.955
Data Source:  STRINGDB
B4GALT3
Tbio
Family:  Enzyme
Novelty:  0.04015046
Score:  0.95
Data Source:  STRINGDB
ST6GAL1
Tchem
Family:  Enzyme
Novelty:  0.00274127
Score:  0.818
Data Source:  STRINGDB
NANS
Tbio
Family:  Enzyme
Novelty:  0.00718044
Score:  0.779
Data Source:  STRINGDB
CMAS
Tbio
Family:  Enzyme
Novelty:  0.04295627
Score:  0.756
Data Source:  STRINGDB
B3GALT1
Tbio
Family:  Enzyme
Novelty:  0.14518755
Score:  0.747
Data Source:  STRINGDB
B4GALNT2
Tbio
Family:  Enzyme
Novelty:  0.00499206
Score:  0.717
Data Source:  STRINGDB
SLC5A7
Tchem
Family:  Transporter
Novelty:  0.00232251
Score:  0.689
Data Source:  STRINGDB
SLC37A3
Tdark
Family:  Transporter
Novelty:  0.21571546
Score:  0.674
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Sialic acid metabolism
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
Post-translational protein modification
Sialic acid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
4
4
88
educational attainment
1
4
4
85.9
inflammatory biomarker measurement
1
2
0
43
51.9
cognitive function measurement
1
1
1
45
self reported educational attainment
1
1
1
14.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
88
educational attainment
4
85.9
inflammatory biomarker measurement
0
43
51.9
cognitive function measurement
1
45
self reported educational attainment
1
14.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ST6 beta-galactoside alpha-2,6-sialyltransferase 2
VGNC:10299
450198
Macaque
ST6 beta-galactoside alpha-2,6-sialyltransferase 2
713552
Mouse
MGI:2445190
240119
Rat
RGD:1559663
301155
Dog
ST6 beta-galactoside alpha-2,6-sialyltransferase 2
VGNC:46857
481315
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ST6 beta-galactoside alpha-2,6-sialyltransferase 2
Macaque
ST6 beta-galactoside alpha-2,6-sialyltransferase 2
Mouse
Rat
Dog
ST6 beta-galactoside alpha-2,6-sialyltransferase 2
Publication Statistics
PubMed Score 42.30
PubMed score by year
PubTator Score 96.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title