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Tchem
ST6GAL1
Beta-galactoside alpha-2,6-sialyltransferase 1

Protein Summary
Description
Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates. This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000169298
  • ENSP00000169298
  • ENSG00000073849
  • ENST00000448044
  • ENSP00000389337
  • ENST00000457772
  • ENSP00000412221

Symbol
  • SIAT1
  • ST6N
  • SIAT1
  • ST6GalI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.96
kinase perturbation
0.95
cellular component
0.87
transcription factor binding site profile
0.87
disease perturbation
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 410.24   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 524   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 410.24   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 524   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (13)
CHEMBL3629697
Rendered image for CHEMBL3629697
CHEMBL4102509
Rendered image for CHEMBL4102509
CHEMBL4091389
Rendered image for CHEMBL4091389
CHEMBL3629696
Rendered image for CHEMBL3629696
CHEMBL3629698
Rendered image for CHEMBL3629698
CHEMBL4063545
Rendered image for CHEMBL4063545
CHEMBL4097206
Rendered image for CHEMBL4097206
CHEMBL4081024
Rendered image for CHEMBL4081024
CHEMBL4083608
Rendered image for CHEMBL4083608
Protein-Protein Interactions (148)
ARFGEF3
Tdark
Novelty:  0.20402365
p_int:  0.999981773
p_ni:  0.000018227
p_wrong:  1e-9
Score:  0.167
Data Source:  BioPlex,STRINGDB
ATRIP
Tbio
Novelty:  0.01415267
p_int:  0.999473465
p_ni:  0.000526534
p_wrong:  1e-9
Score:  0.167
Data Source:  BioPlex,STRINGDB
WAPL
Tbio
Novelty:  0.01598061
p_int:  0.995357106
p_ni:  0.004642881
p_wrong:  1.3e-8
Score:  0.181
Data Source:  BioPlex,STRINGDB
ZYG11B
Tbio
Novelty:  0.14657862
p_int:  0.975980388
p_ni:  0.024019612
Data Source:  BioPlex
GLMN
Tbio
Novelty:  0.01940401
p_int:  0.972738261
p_ni:  0.027261726
p_wrong:  1.3e-8
Data Source:  BioPlex
HOOK2
Tbio
Novelty:  0.03559628
p_int:  0.969028325
p_ni:  0.030954951
p_wrong:  0.000016724
Data Source:  BioPlex
SAAL1
Tdark
Novelty:  0.33089811
p_int:  0.966531645
p_ni:  0.033468339
p_wrong:  1.6e-8
Data Source:  BioPlex
USP28
Tchem
Family:  Enzyme
Novelty:  0.02432294
p_int:  0.960717619
p_ni:  0.037204323
p_wrong:  0.002078058
Score:  0.158
Data Source:  BioPlex,STRINGDB
PRMT9
Tbio
Family:  Enzyme
Novelty:  0.26898134
p_int:  0.94606668
p_ni:  0.03938499
p_wrong:  0.01454833
Score:  0.189
Data Source:  BioPlex,STRINGDB
TNPO3
Tbio
Novelty:  0.01709028
p_int:  0.93299668
p_ni:  0.06700332
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
N-Glycan antennae elongation
Reactome
N-glycan antennae elongation in the medial/trans-Golgi
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
N-Glycan antennae elongation
N-glycan antennae elongation in the medial/trans-Golgi
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adiponectin measurement
6
5
6
98.6
BMI-adjusted adiponectin measurement
1
5
5
97.2
6
4
3
1.1
92.4
serum non-albumin protein measurement
2
3
3
90.5
serum IgG glycosylation measurement
1
1
1
88.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adiponectin measurement
6
98.6
BMI-adjusted adiponectin measurement
5
97.2
3
1.1
92.4
serum non-albumin protein measurement
3
90.5
serum IgG glycosylation measurement
1
88.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
VGNC:2593
460922
Macaque
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
708113
Mouse
MGI:108470
20440
Rat
RGD:3676
25197
Dog
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
VGNC:46856
478668
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
Macaque
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
Mouse
Rat
Dog
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
Publication Statistics
PubMed Score 410.24
PubMed score by year
PubTator Score 138.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title