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Tchem
ST6GAL1
Beta-galactoside alpha-2,6-sialyltransferase 1

Protein Summary
Description
Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates. This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000169298
  • ENSP00000169298
  • ENSG00000073849
  • ENST00000448044
  • ENSP00000389337
  • ENST00000457772
  • ENSP00000412221

Symbol
  • SIAT1
  • ST6N
  • SIAT1
  • ST6GalI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.96
kinase perturbation
0.95
cellular component
0.87
transcription factor binding site profile
0.87
disease perturbation
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 486.18   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 524   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 486.18   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 524   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0