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Tbio
ST3GAL4
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

Protein Summary
Description
Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, and NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant. This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227495
  • ENSP00000227495
  • ENSG00000110080
  • ENST00000356132
  • ENSP00000348451
  • ENST00000392669
  • ENSP00000376437
  • ENST00000444328
  • ENSP00000394354
  • ENST00000449406
  • ENSP00000399444
  • ENST00000526727
  • ENSP00000436047
  • ENST00000530591
  • ENSP00000433989
  • ENST00000532243
  • ENSP00000434349
  • ENST00000534083
  • ENSP00000433318
  • ENST00000534457
  • ENSP00000434668

Symbol
  • CGS23
  • NANTA3
  • SIAT4C
  • STZ
  • STZ
  • SAT3
  • ST-4
  • CGS23
  • SIAT4
  • NANTA3
  • SIAT4C
  • ST3GalIV
  • ST3GalA.2
  • gal-NAc6S
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
transcription factor
0.8
trait
0.75
transcription factor binding site profile
0.75
cellular component
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 307.74   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 307.74   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0