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Tbio
ST3GAL4
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

Protein Summary
Description
Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, and NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant. This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227495
  • ENSP00000227495
  • ENSG00000110080
  • ENST00000356132
  • ENSP00000348451
  • ENST00000392669
  • ENSP00000376437
  • ENST00000444328
  • ENSP00000394354
  • ENST00000449406
  • ENSP00000399444
  • ENST00000526727
  • ENSP00000436047
  • ENST00000530591
  • ENSP00000433989
  • ENST00000532243
  • ENSP00000434349
  • ENST00000534083
  • ENSP00000433318
  • ENST00000534457
  • ENSP00000434668

Symbol
  • CGS23
  • NANTA3
  • SIAT4C
  • STZ
  • STZ
  • SAT3
  • ST-4
  • CGS23
  • SIAT4
  • NANTA3
  • SIAT4C
  • ST3GalIV
  • ST3GalA.2
  • gal-NAc6S
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
transcription factor
0.8
trait
0.75
transcription factor binding site profile
0.75
cellular component
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.89   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.89   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (126)
FAM3C
Tbio
Novelty:  0.04598347
p_int:  0.998400034
p_ni:  0.001104246
p_wrong:  0.000495721
Score:  0.183
Data Source:  BioPlex,STRINGDB
DHFR2
Tbio
Family:  Enzyme
Novelty:  0.02374466
p_int:  0.998333086
p_ni:  0.001666914
Score:  0.694
Data Source:  BioPlex,STRINGDB
LCN6
Tbio
Novelty:  0.11406686
p_int:  0.982164441
p_ni:  0.017503625
p_wrong:  0.000331934
Data Source:  BioPlex
CRP
Tbio
Novelty:  0.00001517
p_int:  0.963087339
p_ni:  0.036138964
p_wrong:  0.000773696
Data Source:  BioPlex
PTCH1
Tbio
Novelty:  0.00077635
p_int:  0.940565776
p_ni:  0.055746855
p_wrong:  0.003687369
Data Source:  BioPlex
CSGALNACT2
Tbio
Family:  Enzyme
Novelty:  0.0770692
p_int:  0.91464105
p_ni:  0.08535895
Score:  0.23
Data Source:  BioPlex,STRINGDB
PSCA
Tbio
Novelty:  0.00323778
p_int:  0.909045732
p_ni:  0.090363122
p_wrong:  0.000591146
Data Source:  BioPlex
LRFN3
Tdark
Novelty:  0.30018245
p_int:  0.907313926
p_ni:  0.092686074
Score:  0.547
Data Source:  BioPlex,STRINGDB
MANEAL
Tdark
Family:  Enzyme
Novelty:  0.71535497
p_int:  0.906630818
p_ni:  0.091990715
p_wrong:  0.001378467
Score:  0.548
Data Source:  BioPlex,STRINGDB
PLAUR
Tchem
Family:  Enzyme
Novelty:  0.00087642
p_int:  0.849853415
p_ni:  0.135023825
p_wrong:  0.01512276
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (26)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Blood group systems biosynthesis
Reactome
Glycosaminoglycan metabolism
Reactome
Keratan sulfate biosynthesis
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Blood group systems biosynthesis
Glycosaminoglycan metabolism
Keratan sulfate biosynthesis
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (37)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
4
4
3
15.2
98.7
low density lipoprotein cholesterol measurement
10
14
22
98.6
apolipoprotein B measurement
2
5
5
97.8
total cholesterol measurement
6
9
17
96.1
mean platelet volume
3
2
4
94.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
3
15.2
98.7
low density lipoprotein cholesterol measurement
22
98.6
apolipoprotein B measurement
5
97.8
total cholesterol measurement
17
96.1
mean platelet volume
4
94.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
VGNC:49042
466845
Macaque
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
717792
Mouse
MGI:1316743
20443
Rat
RGD:1303068
363040
Dog
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
VGNC:46852
607094
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
Macaque
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
Mouse
Rat
Dog
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
Publication Statistics
PubMed Score 241.89
PubMed score by year
PubTator Score 149.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title