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Tchem
ST3GAL1
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

Protein Summary
Description
Responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O-linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. Correct glycosylation of the encoded protein may be critical to its sialyltransferase activity. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4B. Two transcript variants encoding the same protein have been found for this gene. Other transcript variants may exist, but have not been fully characterized yet. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399640
  • ENSP00000414073
  • ENSG00000008513
  • ENST00000521180
  • ENSP00000428540
  • ENST00000522652
  • ENSP00000430515
  • ENST00000648219
  • ENSP00000497381

Symbol
  • SIAT4
  • SIAT4A
  • ST3O
  • SIAT4A
  • SIATFL
  • ST3GalA
  • ST3GalIA
  • Gal-NAc6S
  • ST3GalA.1
  • ST3GalIA,1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.93
transcription factor perturbation
0.91
transcription factor binding site profile
0.89
gene perturbation
0.88
PubMedID
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.61   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.61   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (138)
GOLPH3
Tbio
Novelty:  0.00020234
p_int:  0.997501922
p_ni:  0.002495983
p_wrong:  0.000002094
Score:  0.251
Data Source:  BioPlex,STRINGDB
ASPHD2
Tdark
Family:  Enzyme
Novelty:  1.24088719
p_int:  0.978486311
p_ni:  0.021470028
p_wrong:  0.000043661
Data Source:  BioPlex
SLC30A7
Tbio
Family:  Transporter
Novelty:  0.02998245
p_int:  0.944470756
p_ni:  0.055529244
Score:  0.187
Data Source:  BioPlex,STRINGDB
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.932404023
p_ni:  0.067595977
Data Source:  BioPlex
ITGAV
Tchem
Novelty:  0.00148589
p_int:  0.927776674
p_ni:  0.072223326
Score:  0.154
Data Source:  BioPlex,STRINGDB
RMND1
Tbio
Novelty:  0.06181833
p_int:  0.90362607
p_ni:  0.096343422
p_wrong:  0.000030508
Data Source:  BioPlex
ANKRD46
Tbio
Novelty:  0.06546845
p_int:  0.896879495
p_ni:  0.096385484
p_wrong:  0.006735021
Data Source:  BioPlex
C6orf120
Tdark
Novelty:  0.90888293
p_int:  0.883341497
p_ni:  0.11326854
p_wrong:  0.003389962
Score:  0.161
Data Source:  BioPlex,STRINGDB
SLC39A11
Tbio
Family:  Transporter
Novelty:  0.09770302
p_int:  0.870039332
p_ni:  0.129960656
p_wrong:  1.2e-8
Data Source:  BioPlex
UBE2J1
Tbio
Novelty:  0.03619613
p_int:  0.869051305
p_ni:  0.130948666
p_wrong:  3e-8
Score:  0.39
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (22)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Glycosaminoglycan metabolism
Reactome
Keratan sulfate biosynthesis
Reactome
Keratan sulfate/keratin metabolism
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Glycosaminoglycan metabolism
Keratan sulfate biosynthesis
Keratan sulfate/keratin metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
1
1
39.6
aspartate aminotransferase measurement
1
1
0
6.2
37.6
frontal fibrosing alopecia
1
1
0
1.3
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
39.6
aspartate aminotransferase measurement
0
6.2
37.6
frontal fibrosing alopecia
0
1.3
21.5
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
450114
Macaque
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
698004
Mouse
MGI:98304
20442
Rat
RGD:1309373
362924
Dog
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
VGNC:46850
482050
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Macaque
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Mouse
Rat
Dog
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Publication Statistics
PubMed Score 83.61
PubMed score by year
PubTator Score 44.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title