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Tchem
ST14
Suppressor of tumorigenicity 14 protein

Protein Summary
Description
Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing. The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278742
  • ENSP00000278742
  • ENSG00000149418

Symbol
  • PRSS14
  • SNC19
  • TADG15
  • HAI
  • MTSP1
  • SNC19
  • ARCI11
  • MT-SP1
  • PRSS14
  • TADG15
  • TMPRSS14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
PubMedID
0.85
biological term
0.82
virus perturbation
0.76
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 429.58   (req: < 5)
Gene RIFs: 104   (req: <= 3)
Antibodies: 393   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 429.58   (req: >= 5)
Gene RIFs: 104   (req: > 3)
Antibodies: 393   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 278
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3