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Tclin
SSTR4
Somatostatin receptor type 4

Protein Summary
Description
Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells. Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255008
  • ENSP00000255008
  • ENSG00000132671

Symbol
  • SS4R
  • SS4-R
  • SS-4-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.83
biological process
0.82
ligand (chemical)
0.76
tissue sample
0.76
cell line
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.35   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.35   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 86
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (273)
SST
Tbio
Novelty:  0.00005944
Score:  0.995
Data Source:  STRINGDB
CORT
Tbio
Novelty:  0.00789975
Score:  0.969
Data Source:  STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.954
Data Source:  STRINGDB
NPB
Tdark
Novelty:  0.00936692
Score:  0.941
Data Source:  STRINGDB
NPW
Tbio
Novelty:  0.03174263
Score:  0.938
Data Source:  STRINGDB
NPY
Tbio
Novelty:  0.00012637
Score:  0.937
Data Source:  STRINGDB
HTR5A
Tchem
Family:  GPCR
Novelty:  0.0160551
Score:  0.936
Data Source:  STRINGDB
PPY
Tbio
Novelty:  0.00060933
Score:  0.934
Data Source:  STRINGDB
CNR1
Tclin
Family:  GPCR
Novelty:  0.00060063
Score:  0.933
Data Source:  STRINGDB
GAL
Tbio
Novelty:  0.0005132
Score:  0.932
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thrombomodulin measurement
1
1
1
88.5
blood protein measurement
1
1
1
83.5
1
2
0
2.2
24.4
cognitive function measurement
1
1
1
3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thrombomodulin measurement
1
88.5
blood protein measurement
1
83.5
0
2.2
24.4
cognitive function measurement
1
3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
somatostatin receptor 4
VGNC:14303
469897
Macaque
somatostatin receptor 4
702017
Mouse
MGI:105372
20608
Rat
RGD:3764
25555
Chicken
somatostatin receptor 4
CGNC:53401
428547
Species
Name
OMA
EggNOG
Inparanoid
Chimp
somatostatin receptor 4
Macaque
somatostatin receptor 4
Mouse
Rat
Chicken
somatostatin receptor 4
Publication Statistics
PubMed Score 55.35
PubMed score by year
PubTator Score 65.02
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title