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Tclin
SSTR2
Somatostatin receptor type 2

Protein Summary
Description
Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. Somatostatin acts at many sites to inhibit the release of many hormones and other secretory protein ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
1
disease perturbation
0.79
biological term
0.77
biological process
0.68
virus perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 582.86   (req: < 5)
Gene RIFs: 132   (req: <= 3)
Antibodies: 348   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 582.86   (req: >= 5)
Gene RIFs: 132   (req: > 3)
Antibodies: 348   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 254
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (295)
SST
Tbio
Novelty:  0.00005944
Score:  0.997
Data Source:  STRINGDB
CORT
Tbio
Novelty:  0.00789975
Score:  0.969
Data Source:  STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.957
Data Source:  STRINGDB
GNAI1
Tbio
Novelty:  0.0488971
Score:  0.954
Data Source:  STRINGDB
PPY
Tbio
Novelty:  0.00060933
Score:  0.94
Data Source:  STRINGDB
SSTR3
Tclin
Family:  GPCR
Novelty:  0.00899073
Score:  0.94
Data Source:  STRINGDB
NPY
Tbio
Novelty:  0.00012637
Score:  0.94
Data Source:  STRINGDB
GNAI2
Tchem
Novelty:  0.03014729
Score:  0.937
Data Source:  STRINGDB
CNR1
Tclin
Family:  GPCR
Novelty:  0.00060063
Score:  0.937
Data Source:  STRINGDB
NPB
Tdark
Novelty:  0.00936692
Score:  0.936
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (42)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
2
3
79.2
mean reticulocyte volume
1
1
1
74.6
mean corpuscular volume
1
1
1
71.9
mean corpuscular hemoglobin concentration
1
1
1
64.9
reticulocyte count
2
2
2
57.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
79.2
mean reticulocyte volume
1
74.6
mean corpuscular volume
1
71.9
mean corpuscular hemoglobin concentration
1
64.9
reticulocyte count
2
57.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
somatostatin receptor 2
695526
Mouse
MGI:98328
20606
Rat
RGD:3763
54305
Dog
somatostatin receptor 2
VGNC:46844
403472
Horse
somatostatin receptor 2
VGNC:23621
100052744
Species
Name
OMA
EggNOG
Inparanoid
Macaque
somatostatin receptor 2
Mouse
Rat
Dog
somatostatin receptor 2
Horse
somatostatin receptor 2
Publication Statistics
PubMed Score 582.86
PubMed score by year
PubTator Score 434.73
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title