Protein Summary
Somatostatin inhibits the release of somatotropin. The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008]
- ENST00000287641
- ENSP00000287641
- ENSG00000157005
- SMST
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.77 | ||
disease | 0.76 | ||
kinase perturbation | 0.76 | ||
gene perturbation | 0.73 | ||
chemical | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16342.69 (req: < 5)
Gene RIFs: 78 (req: <= 3)
Antibodies: 491 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16342.69 (req: >= 5)
Gene RIFs: 78 (req: > 3)
Antibodies: 491 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (443)
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (25)
Reactome (12)
KEGG (3)
PathwayCommons (6)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Gene expression (Transcription) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Gene expression (Transcription) | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (1)
Components (3)
Processes (15)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
basophil percentage of leukocytes | 2 | 2 | 2 | 79.3 | |||||
body height | 1 | 1 | 1 | 66 | |||||
basophil count | 2 | 2 | 2 | 65.9 | |||||
monocyte percentage of leukocytes | 1 | 1 | 1 | 64 | |||||
basophil percentage of granulocytes | 1 | 1 | 1 | 53.7 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
basophil percentage of leukocytes | 2 | 79.3 | |||||
body height | 1 | 66 | |||||
basophil count | 2 | 65.9 | |||||
monocyte percentage of leukocytes | 1 | 64 | |||||
basophil percentage of granulocytes | 1 | 53.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | somatostatin | 708626 | ||||||
Mouse | MGI:98326 | 20604 | ||||||
Rat | RGD:3761 | 24797 | ||||||
Dog | somatostatin | VGNC:46842 | 403993 | |||||
Horse | somatostatin | VGNC:23619 | 100059610 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | somatostatin | |||||
Mouse | ||||||
Rat | ||||||
Dog | somatostatin | |||||
Horse | somatostatin | |||||
Publication Statistics
PubMed Score 16342.69
PubMed score by year
PubTator Score 1964.62
PubTator score by year
Related Publications
Text Mined References (99)
GeneRif Annotations (78)
Items per page:
0 of 0
PMID | Year | Title |
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