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Tdark
SSSCA1
Sjoegren syndrome/scleroderma autoantigen 1

Protein Summary
Description
Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies. This antigen is recognized by a subset of anti-centromere antibodies from patients with scleroderma and/or Sjogren's syndrome. Subcellular localization has not yet been established. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309328
  • ENSP00000312318
  • ENSG00000173465

Symbol
  • p27
  • SSSCA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.92
kinase perturbation
0.71
tissue sample
0.59
PubMedID
0.54
cell line
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.21   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.21   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (129)
RPUSD4
Tdark
Family:  Enzyme
Novelty:  0.39210095
p_int:  0.999999326
p_ni:  6.74e-7
Data Source:  BioPlex
RAPGEF6
Tbio
Novelty:  0.07979293
p_int:  0.999999299
p_ni:  7.01e-7
Data Source:  BioPlex
TNKS2
Tchem
Family:  Enzyme
Novelty:  0.00938509
p_int:  0.999998775
p_ni:  0.000001223
p_wrong:  1e-9
Data Source:  BioPlex
PIF1
Tbio
Family:  Enzyme
Novelty:  0.00449506
p_int:  0.999998693
p_ni:  0.000001303
p_wrong:  4e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
TNKS
Tchem
Family:  Enzyme
Novelty:  0.00404545
p_int:  0.999997767
p_ni:  0.000002233
Data Source:  BioPlex
LSM11
Tbio
Novelty:  0.10694492
p_int:  0.999995272
p_ni:  0.000004728
Data Source:  BioPlex
SNX33
Tbio
Novelty:  0.11762505
p_int:  0.999980358
p_ni:  0.000019642
Data Source:  BioPlex
ARHGEF39
Tdark
Novelty:  0.30447134
p_int:  0.999978453
p_ni:  0.000013204
p_wrong:  0.000008343
Data Source:  BioPlex
TNIP2
Tbio
Novelty:  0.03640252
p_int:  0.999974215
p_ni:  0.000024837
p_wrong:  9.48e-7
Data Source:  BioPlex
MAP7
Tbio
Novelty:  0.01976296
p_int:  0.999955034
p_ni:  0.000044966
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (40)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
4
5
97.8
heel bone mineral density
3
5
7
95.1
urate measurement
3
3
3
93.3
mean platelet volume
3
2
3
93.2
BMI-adjusted waist-hip ratio
5
4
6
90.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
5
97.8
heel bone mineral density
7
95.1
urate measurement
3
93.3
mean platelet volume
3
93.2
BMI-adjusted waist-hip ratio
6
90.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Sjogren syndrome/scleroderma autoantigen 1
104001215
Mouse
MGI:1913482
56390
Rat
RGD:1593467
689397
Dog
Sjogren syndrome/scleroderma autoantigen 1
476024
Horse
Sjogren syndrome/scleroderma autoantigen 1
100057163
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Sjogren syndrome/scleroderma autoantigen 1
Mouse
Rat
Dog
Sjogren syndrome/scleroderma autoantigen 1
Horse
Sjogren syndrome/scleroderma autoantigen 1
Publication Statistics
PubMed Score 2.21
PubMed score by year
PubTator Score 490.71
PubTator score by year
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Related Publications
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PMID
Year
Title