Tbio SSR3 Translocon-associated protein subunit gamma

Protein Summary

Description

TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR is comprised of four membrane proteins/subunits: alpha, beta, gamma, and delta. The first two are glycosylated subunits and the latter two are non-glycosylated subunits. This gene encodes the gamma subunit, which is predicted to span the membrane four times. [provided by RefSeq, Aug 2010]

Uniprot Accession IDs

• Q9UNL2
• B2R7D0
• B4E2P2
• D3DNK5
• Q549M4
• TRAP-gamma

Gene Name

• SSR3

Ensembl ID

• ENST00000265044
• ENSP00000265044
• ENSG00000114850
• ENST00000467789
• ENSP00000420641

Symbol

• TRAPG
• TRAPG

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.83
kinase perturbation	0.81
microRNA	0.81
transcription factor perturbation	0.8
transcription factor binding site profile	0.78

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.62   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 51   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.62   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0