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Tbio
SSPN
Sarcospan

Protein Summary
Description
Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC. This gene encodes a member of the dystrophin-glycoprotein complex (DGC). The DGC spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Two alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242729
  • ENSP00000242729
  • ENSG00000123096
  • ENST00000422622
  • ENSP00000396087
  • ENST00000540266
  • ENSP00000442893

Symbol
  • KRAG
  • KRAG
  • NSPN
  • SPN1
  • SPN2
  • DAGA5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.72
kinase perturbation
0.71
microRNA
0.67
small molecule perturbation
0.65
transcription factor perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.28   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.28   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
SGCD
Tbio
Novelty:  0.00501907
Score:  0.937
Data Source:  STRINGDB
DMD
Tclin
Novelty:  0.00025661
Score:  0.934
Data Source:  STRINGDB
SGCA
Tbio
Novelty:  0.00442268
Score:  0.932
Data Source:  STRINGDB
UTRN
Tchem
Novelty:  0.0018541
Score:  0.929
Data Source:  STRINGDB
SGCE
Tbio
Novelty:  0.00449577
Score:  0.921
Data Source:  STRINGDB
SGCB
Tbio
Novelty:  0.00970061
Score:  0.92
Data Source:  STRINGDB
SGCG
Tbio
Novelty:  0.0064966
Score:  0.915
Data Source:  STRINGDB
SNTA1
Tbio
Novelty:  0.01668288
Score:  0.899
Data Source:  STRINGDB
DAG1
Tbio
Family:  Enzyme
Novelty:  0.00149278
Score:  0.884
Data Source:  STRINGDB
CAV3
Tbio
Novelty:  0.00190092
Score:  0.873
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
LIFEdb
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (38)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
11
37
81
99.4
balding measurement
2
3
3
97.7
waist-hip ratio
4
3
5
97.4
BMI-adjusted waist circumference
3
16
26
94.5
1
5
5
92.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
81
99.4
balding measurement
3
97.7
waist-hip ratio
5
97.4
BMI-adjusted waist circumference
26
94.5
5
92.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sarcospan
VGNC:5601
739128
Macaque
sarcospan
708482
Mouse
MGI:1353511
16651
Rat
RGD:1559723
500364
Dog
sarcospan
VGNC:54366
100684937
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sarcospan
Macaque
sarcospan
Mouse
Rat
Dog
sarcospan
Publication Statistics
PubMed Score 97.28
PubMed score by year
PubTator Score 30.22
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title