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Tbio
SSH3
Protein phosphatase Slingshot homolog 3

Protein Summary
Description
Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity). The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308127
  • ENSP00000312081
  • ENSG00000172830
  • ENST00000376757
  • ENSP00000365948
  • ENST00000532881
  • ENSP00000431788

Symbol
  • SSH3L
  • SSH3L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
histone modification site profile
0.79
molecular function
0.6
tissue
0.59
transcription factor
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.94   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.94   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
KDM5C
Tchem
Family:  TF; Epigenetic
Novelty:  0.00701855
p_int:  0.999114554
p_ni:  0.000885361
p_wrong:  8.4e-8
Score:  0.225
Data Source:  BioPlex,STRINGDB
HERC1
Tbio
Family:  Enzyme
Novelty:  0.04318441
p_int:  0.998753774
p_ni:  0.001246226
Score:  0.19
Data Source:  BioPlex,STRINGDB
FMC1
Tbio
Novelty:  0.06702205
p_int:  0.998342741
p_ni:  0.001656823
p_wrong:  4.36e-7
Score:  0.164
Data Source:  BioPlex,STRINGDB
KIAA0232
Tdark
Novelty:  2.37569744
p_int:  0.997349852
p_ni:  0.00264848
p_wrong:  0.000001668
Data Source:  BioPlex
JMJD4
Tbio
Novelty:  0.09951585
p_int:  0.926088654
p_ni:  0.073859944
p_wrong:  0.000051403
Score:  0.183
Data Source:  BioPlex,STRINGDB
PSME3
Tbio
Novelty:  0.01051254
p_int:  0.898416159
p_ni:  0.101583841
Data Source:  BioPlex
MKS1
Tbio
Novelty:  0.02463305
p_int:  0.820411635
p_ni:  0.179588097
p_wrong:  2.68e-7
Data Source:  BioPlex
POLA2
Tbio
Family:  Enzyme
Novelty:  0.07371844
p_int:  0.81089969
p_ni:  0.18908622
p_wrong:  0.00001409
Score:  0.192
Data Source:  BioPlex,STRINGDB
YBEY
Tdark
Family:  Enzyme
Novelty:  0.02778029
p_int:  0.80621042
p_ni:  0.193789574
p_wrong:  6e-9
Data Source:  BioPlex
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.800812528
p_ni:  0.199187472
Score:  0.288
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
2
2
3
92.7
mean corpuscular volume
1
1
1
83.8
BMI-adjusted hip circumference
1
1
1
82.5
waist circumference
1
1
1
71.5
red blood cell distribution width
1
1
1
60.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
3
92.7
mean corpuscular volume
1
83.8
BMI-adjusted hip circumference
1
82.5
waist circumference
1
71.5
red blood cell distribution width
1
60.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
slingshot protein phosphatase 3
VGNC:11652
451365
Macaque
slingshot protein phosphatase 3
712699
Mouse
MGI:2683546
245857
Rat
RGD:1308679
365396
Dog
slingshot protein phosphatase 3
VGNC:46833
483699
Species
Name
OMA
EggNOG
Inparanoid
Chimp
slingshot protein phosphatase 3
Macaque
slingshot protein phosphatase 3
Mouse
Rat
Dog
slingshot protein phosphatase 3
Publication Statistics
PubMed Score 7.94
PubMed score by year
PubTator Score 2.31
PubTator score by year
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Related Publications
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PMID
Year
Title