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Tbio
SSH2
Protein phosphatase Slingshot homolog 2

Protein Summary
Description
Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. This gene encodes a protein tyrosine phosphatase that plays a key role in the regulation of actin filaments. The encoded protein dephosphorylates and activates cofilin, which promotes actin filament depolymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269033
  • ENSP00000269033
  • ENSG00000141298

Symbol
  • KIAA1725
  • SSH2L
  • SSH-2
  • SSH-2L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor binding site profile
0.91
histone modification site profile
0.89
microRNA
0.67
transcription factor
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.12   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 47   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.12   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
HECTD1
Tbio
Family:  Enzyme
Novelty:  0.28016112
p_int:  0.944727858
p_ni:  0.055272142
Data Source:  BioPlex
DMKN
Tbio
Novelty:  0.08303199
p_int:  0.784454353
p_ni:  0.000335904
p_wrong:  0.215209743
Data Source:  BioPlex
ARG1
Tchem
Family:  Enzyme
Novelty:  0.00063728
p_int:  0.762486866
p_ni:  0.237513134
Data Source:  BioPlex
CFL1
Tbio
Novelty:  0.00071544
Score:  0.977
Data Source:  STRINGDB
LIMK1
Tchem
Family:  Kinase
Novelty:  0.00349854
Score:  0.905
Data Source:  STRINGDB
CFL2
Tbio
Novelty:  0.01563343
Score:  0.885
Data Source:  STRINGDB
SSH1
Tbio
Family:  Enzyme
Novelty:  0.02079383
Score:  0.825
Data Source:  STRINGDB
SSH3
Tbio
Family:  Enzyme
Novelty:  0.11388661
Score:  0.821
Data Source:  STRINGDB
RNF135
Tbio
Family:  Enzyme
Novelty:  0.05600338
Score:  0.744
Data Source:  STRINGDB
PPP3CB
Tbio
Family:  Enzyme
Novelty:  0.02156713
Score:  0.704
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
3
4
94.5
monocyte count
2
2
2
93.6
leukocyte count
2
2
2
90.5
neutrophil count
2
2
2
88.2
lymphocyte count
3
3
3
86.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
94.5
monocyte count
2
93.6
leukocyte count
2
90.5
neutrophil count
2
88.2
lymphocyte count
3
86.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
slingshot protein phosphatase 2
VGNC:12698
454551
Macaque
slingshot protein phosphatase 2
711898
Mouse
MGI:2679255
237860
Rat
RGD:1309389
303342
Dog
slingshot protein phosphatase 2
VGNC:46832
491183
Species
Name
OMA
EggNOG
Inparanoid
Chimp
slingshot protein phosphatase 2
Macaque
slingshot protein phosphatase 2
Mouse
Rat
Dog
slingshot protein phosphatase 2
Publication Statistics
PubMed Score 20.12
PubMed score by year
PubTator Score 4.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title