You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SSH1
Protein phosphatase Slingshot homolog 1

Protein Summary
Description
Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [prov ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326470
  • ENSP00000326107
  • ENSG00000084112
  • ENST00000326495
  • ENSP00000315713
  • ENST00000551165
  • ENSP00000448824

Symbol
  • KIAA1298
  • SSH1L
  • SSH1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
transcription factor perturbation
0.91
transcription factor
0.78
transcription factor binding site profile
0.78
microRNA
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.26   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.26   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.994231215
p_ni:  0.005768785
Score:  0.185
Data Source:  BioPlex,STRINGDB
GSN
Tbio
Novelty:  0.00060852
p_int:  0.987380322
p_ni:  0.012619678
Score:  0.907
Data Source:  BioPlex,STRINGDB
ACTA2
Tbio
Novelty:  0.00199354
p_int:  0.961821548
p_ni:  0.038178448
p_wrong:  4e-9
Score:  0.321
Data Source:  BioPlex,STRINGDB
TMOD2
Tbio
Novelty:  0.10324176
p_int:  0.929477241
p_ni:  0.070522759
Score:  0.79
Data Source:  BioPlex,STRINGDB
ACTB
Tbio
Novelty:  0.00006048
p_int:  0.912692299
p_ni:  0.087307701
Score:  0.379
Data Source:  BioPlex,STRINGDB
YWHAZ
Tchem
Novelty:  0.00210582
p_int:  0.805841973
p_ni:  0.194158027
Score:  0.596
Data Source:  BioPlex,STRINGDB
TMOD3
Tbio
Novelty:  0.04744699
p_int:  0.788139835
p_ni:  0.211860165
Score:  0.724
Data Source:  BioPlex,STRINGDB
YWHAG
Tchem
Novelty:  0.00845572
p_int:  0.774285309
p_ni:  0.225714691
Score:  0.295
Data Source:  BioPlex,STRINGDB
CFL1
Tbio
Novelty:  0.00071544
Score:  0.993
Data Source:  STRINGDB
PAK4
Tchem
Family:  Kinase
Novelty:  0.0068821
Score:  0.961
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
3
92.2
platelet count
1
1
1
56.4
serum gamma-glutamyl transferase measurement
1
1
1
45.5
reticulocyte measurement
1
1
1
44.2
serum non-albumin protein measurement
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
92.2
platelet count
1
56.4
serum gamma-glutamyl transferase measurement
1
45.5
reticulocyte measurement
1
44.2
serum non-albumin protein measurement
1
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
slingshot protein phosphatase 1
707809
Mouse
MGI:2686240
231637
Rat
RGD:1306038
304580
Dog
slingshot protein phosphatase 1
VGNC:46831
477526
Horse
slingshot protein phosphatase 1 [Source:HGNC Symbol;Acc:HGNC:30579]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
slingshot protein phosphatase 1
Mouse
Rat
Dog
slingshot protein phosphatase 1
Horse
slingshot protein phosphatase 1 [Source:HGNC Symbol;Acc:HGNC:30579]
Publication Statistics
PubMed Score 49.26
PubMed score by year
PubTator Score 30.88
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title