Tbio SSH1 Protein phosphatase Slingshot homolog 1

Protein Summary

Description

Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q8WYL5
• Q6P6C0
• Q8N9A7
• Q8WYL3
• Q8WYL4
• Q9P2P8

Gene Name

• SSH1

Ensembl ID

• ENST00000326470
• ENSP00000326107
• ENSG00000084112
• ENST00000326495
• ENSP00000315713
• ENST00000551165
• ENSP00000448824

Symbol

• KIAA1298
• SSH1L
• SSH1L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
transcription factor perturbation	0.91
transcription factor	0.78
transcription factor binding site profile	0.78
microRNA	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.26   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 179   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.26   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (71)

Explore Interacting Targets

1 – 10 of 71

• See Interactions on String-DB

ACTBL2

Tbio

Novelty:  0.18080702

p_int:  0.994231215

p_ni:  0.005768785

Score:  0.185

Data Source:  BioPlex,STRINGDB

GSN

Tbio

Novelty:  0.00060852

p_int:  0.987380322

p_ni:  0.012619678

Score:  0.907

Data Source:  BioPlex,STRINGDB

ACTA2

Tbio

Novelty:  0.00199354

p_int:  0.961821548

p_ni:  0.038178448

p_wrong:  4e-9

Score:  0.321

Data Source:  BioPlex,STRINGDB

TMOD2

Tbio

Novelty:  0.10324176

p_int:  0.929477241

p_ni:  0.070522759

Score:  0.79

Data Source:  BioPlex,STRINGDB

ACTB

Tbio

Novelty:  0.00006048

p_int:  0.912692299

p_ni:  0.087307701

Score:  0.379

Data Source:  BioPlex,STRINGDB

YWHAZ

Tchem

Novelty:  0.00210582

p_int:  0.805841973

p_ni:  0.194158027

Score:  0.596

Data Source:  BioPlex,STRINGDB

TMOD3

Tbio

Novelty:  0.04744699

p_int:  0.788139835

p_ni:  0.211860165

Score:  0.724

Data Source:  BioPlex,STRINGDB

YWHAG

Tchem

Novelty:  0.00845572

p_int:  0.774285309

p_ni:  0.225714691

Score:  0.295

Data Source:  BioPlex,STRINGDB

CFL1

Tbio

Novelty:  0.00071544

Score:  0.993

Data Source:  STRINGDB

PAK4

Tchem

Family:  Kinase

Novelty:  0.0068821

Score:  0.961

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (8)

KEGG (2)

PathwayCommons (3)

WikiPathways (3)

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1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Axon guidance	180 targets	path:hsa04360
KEGG	Regulation of actin cytoskeleton	212 targets	path:hsa04810

Name	Explore in Pharos	Explore in Source
Axon guidance	180 targets	path:hsa04360
Regulation of actin cytoskeleton	212 targets	path:hsa04810

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (26)

Functions (4)

Components (8)

Processes (14)

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1 – 4 of 4

GO Term	Evidence	Assigned by
actin binding	Inferred from Direct Assay (IDA)	UniProtKB
phosphoprotein phosphatase activity	Inferred from Direct Assay (IDA)	UniProtKB
protein tyrosine phosphatase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
protein tyrosine/serine/threonine phosphatase activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (8)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	3	3	3		92.2
platelet count	EFO_0004309	1	1	1		56.4
serum gamma-glutamyl transferase measurement	EFO_0004532	1	1	1		45.5
reticulocyte measurement	EFO_0010700	1	1	1		44.2
serum non-albumin protein measurement	EFO_0004568	1	1	1		38.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	3		92.2
platelet count	EFO_0004309	1		56.4
serum gamma-glutamyl transferase measurement	EFO_0004532	1		45.5
reticulocyte measurement	EFO_0010700	1		44.2
serum non-albumin protein measurement	EFO_0004568	1		38.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Actin-binding
Alternative splicing
Cell projection
Complete proteome
Cytoplasm
Cytoskeleton
Hydrolase
Phosphoprotein
Protein phosphatase

GWAS Trait Find Similar Targets

No Header	No Header
cognitive function measurement
low density lipoprotein cholesterol measurement
mean platelet volume
platelet count
reticulocyte measurement
serum gamma-glutamyl transferase measurement
serum non-albumin protein measurement
total cholesterol measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	slingshot protein phosphatase 1		707809
Mouse	slingshot protein phosphatase 1	MGI:2686240	231637
Rat	slingshot protein phosphatase 1	RGD:1306038	304580
Dog	slingshot protein phosphatase 1	VGNC:46831	477526
Horse	slingshot protein phosphatase 1 [Source:HGNC Symbol;Acc:HGNC:30579]

Species	Name	OMA	EggNOG	Inparanoid
Macaque	slingshot protein phosphatase 1
Mouse	slingshot protein phosphatase 1
Rat	slingshot protein phosphatase 1
Dog	slingshot protein phosphatase 1
Horse	slingshot protein phosphatase 1 [Source:HGNC Symbol;Acc:HGNC:30579]

Publication Statistics

PubMed Score 49.26

PubMed score by year

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PubTator Score 30.88

PubTator score by year

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Related Publications

Text Mined References (43)

GeneRif Annotations (27)

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PMID	Year	Title