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Tdark
SSC4D
Scavenger receptor cysteine-rich domain-containing group B protein

Protein Summary
Description
The scavenger receptor cysteine-rich (SRCR) superfamily is an ancient and highly conserved group of cell surface and/or secreted proteins, some of which are involved in the development of the immune system and the regulation of both innate and adaptive immune responses. Group B SRCR domains usually contain 8 regularly spaced cysteines that give rise to a well-defined intradomain disulfide-bond pattern.[supplied by OMIM, Apr 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275560
  • ENSP00000275560
  • ENSG00000146700

Symbol
  • SRCRB4D
  • SRCRB4D
  • S4D-SRCRB
  • SRCRB-S4D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.75
cell line
0.6
tissue sample
0.52
transcription factor
0.52
tissue
0.43


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.51   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.51   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (10)
TMPRSS15
Tchem
Family:  Enzyme
Novelty:  0.00118305
Score:  0.653
Data Source:  STRINGDB
LDLRAD2
Tdark
Novelty:  1.67238137
Score:  0.585
Data Source:  STRINGDB
FAT3
Tbio
Novelty:  0.03661008
Score:  0.572
Data Source:  STRINGDB
FBXO21
Tbio
Novelty:  0.2186203
Score:  0.559
Data Source:  STRINGDB
H1F0
Tchem
Novelty:  0.00039686
Score:  0.538
Data Source:  STRINGDB
BMP5
Tbio
Novelty:  0.00866987
Score:  0.487
Data Source:  STRINGDB
NUDCD1
Tbio
Novelty:  0.07471096
Score:  0.42
Data Source:  STRINGDB
STAG3
Tbio
Novelty:  0.03329703
Score:  0.414
Data Source:  STRINGDB
GCFC2
Tbio
Novelty:  0.04245608
Score:  0.411
Data Source:  STRINGDB
ABCB6
Tbio
Family:  Transporter
Novelty:  0.00552057
Score:  0.407
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heat shock 27 kDa protein measurement
1
1
1
51.7
triglyceride measurement
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heat shock 27 kDa protein measurement
1
51.7
triglyceride measurement
1
40.7
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
scavenger receptor cysteine rich family member with 4 domains
VGNC:10332
744680
Mouse
MGI:1924709
109267
Rat
RGD:1306970
304401
Dog
scavenger receptor cysteine rich family member with 4 domains
VGNC:46829
608018
Horse
scavenger receptor cysteine rich family member with 4 domains
VGNC:51247
100060975
Species
Name
OMA
EggNOG
Inparanoid
Chimp
scavenger receptor cysteine rich family member with 4 domains
Mouse
Rat
Dog
scavenger receptor cysteine rich family member with 4 domains
Horse
scavenger receptor cysteine rich family member with 4 domains
Publication Statistics
PubMed Score 1.51
PubMed score by year
PubTator Score 1.07
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title