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Tbio
SSBP2
Single-stranded DNA-binding protein 2

Protein Summary
Description
This gene encodes a subunit of a protein complex that interacts with single-stranded DNA and is involved in the DNA damage response and maintenance of genome stability. The encoded protein may also play a role in telomere repair. A variant of this gene may be associated with survival in human glioblastoma patients. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320672
  • ENSP00000322977
  • ENSG00000145687
  • ENST00000505980
  • ENSP00000423969
  • ENST00000509053
  • ENSP00000422961
  • ENST00000514493
  • ENSP00000426183
  • ENST00000515395
  • ENSP00000424657

Symbol
  • SSDP2
  • HSPC116
  • SOSS-B2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
transcription factor binding site profile
0.92
PubMedID
0.91
disease perturbation
0.87
kinase perturbation
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.31   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.31   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
SSBP3
Tbio
Novelty:  0.01955714
p_int:  1
Score:  0.869
Data Source:  BioPlex,STRINGDB
SSBP4
Tdark
Novelty:  0.27365687
p_int:  1
Score:  0.867
Data Source:  BioPlex,STRINGDB
LMX1B
Tbio
Family:  TF
Novelty:  0.00405645
p_int:  1
Score:  0.768
Data Source:  BioPlex,STRINGDB
ISL2
Tbio
Family:  TF
Novelty:  0.03917372
p_int:  0.999999826
p_ni:  1.74e-7
Score:  0.874
Data Source:  BioPlex,STRINGDB
LDB1
Tbio
Novelty:  0.01110112
p_int:  0.99999976
p_ni:  2.39e-7
Score:  0.967
Data Source:  BioPlex,STRINGDB
LMO1
Tbio
Novelty:  0.01670419
p_int:  0.999999443
p_ni:  5.54e-7
p_wrong:  4e-9
Score:  0.528
Data Source:  BioPlex,STRINGDB
IDI2
Tbio
Family:  Enzyme
Novelty:  0.02715208
p_int:  0.999998707
p_ni:  0.000001292
p_wrong:  1e-9
Score:  0.867
Data Source:  BioPlex,STRINGDB
LHX6
Tbio
Family:  TF
Novelty:  0.01603143
p_int:  0.999997259
p_ni:  0.000002741
Score:  0.759
Data Source:  BioPlex,STRINGDB
LMO2
Tbio
Novelty:  0.0038279
p_int:  0.999993429
p_ni:  0.00000657
p_wrong:  2e-9
Score:  0.77
Data Source:  BioPlex,STRINGDB
LMO4
Tbio
Novelty:  0.08806373
p_int:  0.999992709
p_ni:  0.000001673
p_wrong:  0.000005618
Score:  0.87
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
2
3
79.7
body height
1
1
1
58.9
body weight
1
1
1
56.8
educational attainment
1
3
3
55.2
visceral adipose tissue measurement
1
1
1
50.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
79.7
body height
1
58.9
body weight
1
56.8
educational attainment
3
55.2
visceral adipose tissue measurement
1
50.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
single stranded DNA binding protein 2
VGNC:13602
741132
Macaque
single stranded DNA binding protein 2
711752
Mouse
MGI:1914220
66970
Rat
RGD:1562968
361877
Dog
single stranded DNA binding protein 2
VGNC:46827
479160
Species
Name
OMA
EggNOG
Inparanoid
Chimp
single stranded DNA binding protein 2
Macaque
single stranded DNA binding protein 2
Mouse
Rat
Dog
single stranded DNA binding protein 2
Publication Statistics
PubMed Score 20.31
PubMed score by year
PubTator Score 10.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title