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Tbio
SSB
Lupus La protein

Protein Summary
Description
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597). The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260956
  • ENSP00000260956
  • ENSG00000138385
  • ENST00000409333
  • ENSP00000386636

Symbol
  • La
  • LARP3
  • La/SSB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
ligand (protein) perturbation
0.96
co-expressed gene
0.94
hub protein
0.92
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 457.77   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 480   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 457.77   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 480   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (243)
SURF2
Tdark
Novelty:  0.10662558
p_int:  0.988254579
p_ni:  0.011745421
Score:  0.265
Data Source:  BioPlex,STRINGDB
TRMT2A
Tbio
Family:  Enzyme
Novelty:  0.15277091
p_int:  0.971155304
p_ni:  0.028844696
Score:  0.225
Data Source:  BioPlex,STRINGDB
PUF60
Tbio
Novelty:  0.02667356
p_int:  0.940072443
p_ni:  0.059927557
Score:  0.341
Data Source:  BioPlex,STRINGDB
TROVE2
Tbio
Novelty:  0.00306038
p_int:  0.856216612
p_ni:  0.143783388
Score:  0.876
Data Source:  BioPlex,STRINGDB
HIST1H1E
Tbio
Novelty:  0.01125284
p_int:  0.783549847
p_ni:  0.216450153
Score:  0.201
Data Source:  BioPlex,STRINGDB
PTBP1
Tbio
Novelty:  0.00184728
Score:  0.966
Data Source:  STRINGDB
HNRNPA1
Tchem
Novelty:  0.0020871
Score:  0.953
Data Source:  STRINGDB
HNRNPK
Tbio
Novelty:  0.00354731
Score:  0.953
Data Source:  STRINGDB
NIFK
Tbio
Novelty:  0.01221562
Score:  0.953
Data Source:  STRINGDB
FBL
Tbio
Family:  Enzyme
Novelty:  0.00080634
Score:  0.95
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase III Abortive And Retractive Initiation
Reactome
RNA Polymerase III Transcription
Reactome
RNA Polymerase III Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Transcription
RNA Polymerase III Transcription Termination
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
35.6
platelet count
1
1
1
21.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
35.6
platelet count
1
21.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Sjogren syndrome antigen B
VGNC:2867
459721
Macaque
Sjogren syndrome antigen B
710344
Mouse
MGI:98423
20823
Rat
Dog
Sjogren syndrome antigen B
478787
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Sjogren syndrome antigen B
Macaque
Sjogren syndrome antigen B
Mouse
Rat
Dog
Sjogren syndrome antigen B
Publication Statistics
PubMed Score 457.77
PubMed score by year
PubTator Score 1549.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title