SS18
Protein SSXT
Protein Summary
Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058).
- ENST00000269137
- ENSP00000269137
- ENSG00000141380
- ENST00000415083
- ENSP00000414516
- SSXT
- SYT
- SYT
- SSXT
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.96 | ||
kinase perturbation | 0.91 | ||
disease perturbation | 0.9 | ||
cell type or tissue | 0.82 | ||
histone modification site profile | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 192.39 (req: < 5)
Gene RIFs: 50 (req: <= 3)
Antibodies: 132 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 192.39 (req: >= 5)
Gene RIFs: 50 (req: > 3)
Antibodies: 132 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0