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Tbio
SRSF9
Serine/arginine-rich splicing factor 9

Protein Summary
Description
Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10. The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two pseudogenes, one on chromosome 15 and the other on chromosome 21, have been found for this gene. [provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229390
  • ENSP00000229390
  • ENSG00000111786

Symbol
  • SFRS9
  • SRP30C
  • SFRS9
  • SRp30c
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
1
interacting protein
0.99
kinase perturbation
0.99
ligand (protein) perturbation
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.27   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 223   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.27   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (305)
SNIP1
Tbio
Novelty:  0.01865867
p_int:  0.809960976
p_ni:  0.190039024
Score:  0.236
Data Source:  BioPlex,STRINGDB
NKAPD1
Tdark
Novelty:  1.56979675
p_int:  0.775216008
p_ni:  0.224783992
Score:  0.173
Data Source:  BioPlex,STRINGDB
SRSF7
Tbio
Novelty:  0.03712415
Score:  0.999
Data Source:  STRINGDB
SRSF1
Tbio
Novelty:  0.00074446
Score:  0.998
Data Source:  STRINGDB
TRA2B
Tbio
Novelty:  0.0146833
Score:  0.998
Data Source:  STRINGDB
SRSF2
Tbio
Novelty:  0.00207072
Score:  0.997
Data Source:  STRINGDB
SRSF6
Tbio
Novelty:  0.00396762
Score:  0.993
Data Source:  STRINGDB
SRSF3
Tbio
Novelty:  0.01015895
Score:  0.992
Data Source:  STRINGDB
RBMX
Tbio
Novelty:  0.01705784
Score:  0.989
Data Source:  STRINGDB
SNRNP70
Tbio
Novelty:  0.00116631
Score:  0.987
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
7
11
95.8
C-reactive protein measurement
2
7
7
93.7
reticulocyte measurement
3
3
6
85.4
mean reticulocyte volume
1
2
2
81.5
serum gamma-glutamyl transferase measurement
2
2
2
78.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
11
95.8
C-reactive protein measurement
7
93.7
reticulocyte measurement
6
85.4
mean reticulocyte volume
2
81.5
serum gamma-glutamyl transferase measurement
2
78.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine and arginine rich splicing factor 9
VGNC:14417
742440
Macaque
serine and arginine rich splicing factor 9
697191
Mouse
MGI:104896
108014
Rat
RGD:1309495
288701
Dog
serine and arginine rich splicing factor 9
VGNC:52970
477510
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine and arginine rich splicing factor 9
Macaque
serine and arginine rich splicing factor 9
Mouse
Rat
Dog
serine and arginine rich splicing factor 9
Publication Statistics
PubMed Score 37.27
PubMed score by year
PubTator Score 18.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title