Tbio SRSF5 Serine/arginine-rich splicing factor 5

Protein Summary

Description

Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• Q13243
• O14797
• Q16662
• Q49AD6
• Q6FGE0

Gene Name

• SRSF5

Ensembl ID

• ENST00000394366
• ENSP00000377892
• ENSG00000100650
• ENST00000553521
• ENSP00000452123
• ENST00000553635
• ENSP00000451391
• ENST00000557154
• ENSP00000451088

Symbol

• HRS
• SFRS5
• SRP40
• HRS
• SFRS5
• SRP40

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
hub protein	0.94
transcription factor binding site profile	0.9
transcription factor	0.76
tissue sample	0.71

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Serine/arginine-rich Splicing Factor 5

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Serine/arginine-rich Splicing Factor 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.98   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 102   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.98   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0