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Tbio
SRSF10
Serine/arginine-rich splicing factor 10

Protein Summary
Description
Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250). This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343255
  • ENSP00000344149
  • ENSG00000188529
  • ENST00000344989
  • ENSP00000342913
  • ENST00000374452
  • ENSP00000363576
  • ENST00000453840
  • ENSP00000388991
  • ENST00000484146
  • ENSP00000419813
  • ENST00000492112
  • ENSP00000420195

Symbol
  • FUSIP1
  • FUSIP2
  • SFRS13A
  • TASR
  • NSSR
  • TASR
  • SRp38
  • TASR1
  • TASR2
  • FUSIP1
  • FUSIP2
  • SFRS13
  • SRrp40
  • SFRS13A
  • PPP1R149
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.93
virus perturbation
0.9
transcription factor binding site profile
0.87
ligand (protein) perturbation
0.83
microRNA
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.55   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.55   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (188)
U2AF2
Tbio
Novelty:  0.00590935
p_int:  0.990000998
p_ni:  0.009999002
Score:  0.988
Data Source:  BioPlex,STRINGDB
LUC7L2
Tbio
Novelty:  0.36989457
p_int:  0.987919193
p_ni:  0.012080807
Score:  0.44
Data Source:  BioPlex,STRINGDB
CLK2
Tchem
Family:  Kinase
Novelty:  0.13068449
p_int:  0.98248913
p_ni:  0.01751087
Score:  0.751
Data Source:  BioPlex,STRINGDB
SNIP1
Tbio
Novelty:  0.01865867
p_int:  0.975614047
p_ni:  0.024385953
Score:  0.633
Data Source:  BioPlex,STRINGDB
NKAPD1
Tdark
Novelty:  1.56979675
p_int:  0.963834473
p_ni:  0.036165526
Score:  0.221
Data Source:  BioPlex,STRINGDB
SAP18
Tbio
Family:  Enzyme
Novelty:  0.03918373
p_int:  0.96225494
p_ni:  0.03774506
p_wrong:  1e-9
Score:  0.786
Data Source:  BioPlex,STRINGDB
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.946654467
p_ni:  0.053345532
p_wrong:  1e-9
Score:  0.97
Data Source:  BioPlex,STRINGDB
ZC3H18
Tdark
Novelty:  0.3515546
p_int:  0.91630121
p_ni:  0.08369879
Score:  0.548
Data Source:  BioPlex,STRINGDB
CLK3
Tchem
Family:  Kinase
Novelty:  0.03466191
p_int:  0.906368954
p_ni:  0.093631046
Score:  0.845
Data Source:  BioPlex,STRINGDB
CBLL2
Tdark
Family:  Enzyme
Novelty:  0.27990611
p_int:  0.904643408
p_ni:  0.095356592
Score:  0.204
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
3
83.2
eosinophil percentage of leukocytes
2
2
2
75.9
lymphocyte count
1
1
1
48.8
eosinophil percentage of granulocytes
1
1
1
25.8
red blood cell distribution width
1
1
1
13.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
83.2
eosinophil percentage of leukocytes
2
75.9
lymphocyte count
1
48.8
eosinophil percentage of granulocytes
1
25.8
red blood cell distribution width
1
13.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
serine/arginine-rich splicing factor 10
705832
Mouse
MGI:1333805
14105
Rat
RGD:1311067
362630
Horse
serine and arginine rich splicing factor 10 [Source:HGNC Symbol;Acc:HGNC:16713]
Xenopus
serine/arginine-rich splicing factor 10
XB-GENE-492982
496509
Species
Name
OMA
EggNOG
Inparanoid
Macaque
serine/arginine-rich splicing factor 10
Mouse
Rat
Horse
serine and arginine rich splicing factor 10 [Source:HGNC Symbol;Acc:HGNC:16713]
Xenopus
serine/arginine-rich splicing factor 10
Publication Statistics
PubMed Score 117.55
PubMed score by year
PubTator Score 45.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title