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Tbio
SRSF1
Serine/arginine-rich splicing factor 1

Protein Summary
Description
Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway. This gene encodes a member of the arginine/serine-rich splicing factor protein family. The encoded protein can either activate or repress splicing, depe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258962
  • ENSP00000258962
  • ENSG00000136450
  • ENST00000581979
  • ENSP00000463223
  • ENST00000582730
  • ENSP00000462215

Symbol
  • ASF
  • SF2
  • SF2P33
  • SFRS1
  • ASF
  • SF2
  • SFRS1
  • SF2p33
  • SRp30a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
interacting protein
1
transcription factor perturbation
1
disease perturbation
0.95
transcription factor binding site profile
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1603.43   (req: < 5)
Gene RIFs: 107   (req: <= 3)
Antibodies: 284   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1603.43   (req: >= 5)
Gene RIFs: 107   (req: > 3)
Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (516)
LUC7L2
Tbio
Novelty:  0.36989457
p_int:  0.985215969
p_ni:  0.014784031
Score:  0.539
Data Source:  BioPlex,STRINGDB
SNIP1
Tbio
Novelty:  0.01865867
p_int:  0.979481976
p_ni:  0.020518024
Score:  0.266
Data Source:  BioPlex,STRINGDB
ZC3H18
Tdark
Novelty:  0.3515546
p_int:  0.972768783
p_ni:  0.027231217
Score:  0.551
Data Source:  BioPlex,STRINGDB
SAP18
Tbio
Family:  Enzyme
Novelty:  0.03918373
p_int:  0.967063681
p_ni:  0.032936319
Score:  0.81
Data Source:  BioPlex,STRINGDB
U2AF2
Tbio
Novelty:  0.00590935
p_int:  0.962729144
p_ni:  0.037270856
Score:  0.997
Data Source:  BioPlex,STRINGDB
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.951214041
p_ni:  0.048785959
Score:  0.999
Data Source:  BioPlex,STRINGDB
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.928371242
p_ni:  0.071628758
Score:  0.951
Data Source:  BioPlex,STRINGDB
NKAPD1
Tdark
Novelty:  1.56979675
p_int:  0.896878282
p_ni:  0.103121718
Data Source:  BioPlex
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.85875873
p_ni:  0.14124127
Data Source:  BioPlex
ZC3H3
Tbio
Novelty:  0.26894046
p_int:  0.844340952
p_ni:  0.155659048
Score:  0.291
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
2
3
45.4
gut microbiome measurement
1
1
2
39.3
mean platelet volume
1
1
1
22.8
blood protein measurement
1
1
1
10.7
self reported educational attainment
1
1
1
7.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
45.4
gut microbiome measurement
2
39.3
mean platelet volume
1
22.8
blood protein measurement
1
10.7
self reported educational attainment
1
7.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine and arginine rich splicing factor 1
VGNC:12697
468417
Macaque
serine and arginine rich splicing factor 1
713958
Mouse
MGI:98283
110809
Rat
RGD:1587490
689890
Dog
serine and arginine rich splicing factor 1
VGNC:46816
609693
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine and arginine rich splicing factor 1
Macaque
serine and arginine rich splicing factor 1
Mouse
Rat
Dog
serine and arginine rich splicing factor 1
Publication Statistics
PubMed Score 1603.43
PubMed score by year
PubTator Score 610.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title